C₂₆H₃₁N₄O₁₃PS

Base Information

• Chemical Name: C₂₆H₃₁N₄O₁₃PS
• CAS No.: 1443257-89-3
• Molecular Formula: C₂₆H₃₁N₄O₁₃PS
• Molecular Weight: 670.591
• Mol file: 1443257-89-3.mol

Synonyms:

Chemical Property of C₂₆H₃₁N₄O₁₃PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₁N₄O₁₃PS

There total 8 articles about C₂₆H₃₁N₄O₁₃PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.2%

4-sulfanylphenol (637-89-8) + C26H31N4O12PS (1397776-03-2) → C26H31N4O13PS (1443257-89-3) + thymidylyl (3',5')thymidine (1969-54-6)

Guidance literature:

In water; for 0.0833333h; UV-irradiation; Inert atmosphere;

DOI:10.1002/anie.201209454

Reference yield:

C32H45N4O12PSSi (1397776-01-0) → C26H31N4O13PS (1443257-89-3) + thymidylyl (3',5')thymidine (1969-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere

2: water / 0.08 h / UV-irradiation; Inert atmosphere

With tetrabutyl ammonium fluoride; In tetrahydrofuran; water;

DOI:10.1002/anie.201209454

Reference yield:

C28H46N2O5SSi2 (1397775-96-0) → C26H31N4O13PS (1443257-89-3) + thymidylyl (3',5')thymidine (1969-54-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: water; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

2.1: 4,5-dicyano-1H-imidazole / acetonitrile / 0.5 h / Inert atmosphere

2.2: Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere

4.1: water / 0.08 h / UV-irradiation; Inert atmosphere

With 4,5-dicyano-1H-imidazole; tetrabutyl ammonium fluoride; water; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;

DOI:10.1002/anie.201209454

upstream raw materials:

C₂₈H₄₆N₂O₅SSi₂

C₂₂H₃₂N₂O₅SSi

5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

C₃₂H₄₅N₄O₁₂PSSi