1969-54-6

Usage

Uses

Used in Pharmaceutical Industry:
THYMIDYLYL(3'->5')THYMIDINE AMMONIUM SALT is used as a therapeutic agent for its potential role in skin photo-protection and repair. It aids in the maintenance and restoration of skin health by protecting it from harmful UV radiation and promoting the repair of damaged skin cells.
Used in Cosmetic Industry:
In the cosmetic industry, THYMIDYLYL(3'->5')THYMIDINE AMMONIUM SALT is used as an active ingredient in skincare products for its skin-protective and reparative properties. It helps in the development of formulations that can shield the skin from environmental stressors and enhance the skin's natural repair mechanisms.
Used in Research and Development:
THYMIDYLYL(3'->5')THYMIDINE AMMONIUM SALT is also utilized in research and development for its potential applications in understanding the molecular mechanisms of various diseases and the development of novel therapeutic strategies. Its role in biological processes makes it a valuable compound for scientific investigations and the creation of innovative healthcare solutions.

Upstream product

• 35002-94-9 thymidine 3'-[thymidine 5'-(methyl phosphate)] 
• 365-07-1 thymidine 5'-phosphate 
• 50571-26-1 5'-DMT-thymidine-3'-H-phosphonate 
• 50-89-5 thymidine 
• 4850-55-9 2,2,2-trimethoxy-4,5-diphenyl-2,2-dihydro-1,3,2-dioxaphospholene 
• 68030-66-0 deoxythymidylyl-(5'->3')-deoxythymidine-(Pⁱⁿ->N)-phenylalanine 
• 291525-17-2 3′,5′-bis-O-(tert-butyldimethylsilyl)-5-bromomethyl-2'-deoxyuridine 
• 40733-26-4 3',5'-O-di(tert-butyldimethylsilyl)thymidine 
• 637-89-8 4-sulfanylphenol 
• 1397776-03-2 C₂₆H₃₁N₄O₁₂PS 
• 1397776-01-0 C₃₂H₄₅N₄O₁₂PSSi 
• 98796-51-1 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 
• 1397775-99-3 C₂₂H₃₂N₂O₅SSi 
• 1397775-96-0 C₂₈H₄₆N₂O₅SSi₂ 

Downstream Products

• 50-89-5 thymidine 
• 365-07-1 thymidine 5'-phosphate 

Relevant academic research and scientific papers

2-MERCAPTOBENZOTHIAZOLE-AN IMPROVED REAGENT FOR THE REMOVAL OF METHYL PHOSPHATE PROTECTING GROUPS FROM OLIGODEOXYNUCLEOTIDE PHOSPHOTRIESTERS.

An equimolar (1.5 M) solution of 2-mercaptobenzothiazole and N,N-diisopropylethylamine in 1-methyl-2-pyrrolidinone efficiently removed the methyl phosphate protecting groups from deoxynucleotide phosphotriesters and yielded synthetic oligomers of high genetic integrity.This odorless reagent can therefore substitute for hazardous thiophenol usually used for this purpose.

The 4-oxopentyl group as a labile phosphate/thiophosphate protecting group for synthetic oligodeoxyribonucleotides

An efficient and economical method for the solid-phase synthesis of oligodeoxyribonucleotides and their phosphorothioate analogues is described. The method entails the use of the 4-oxopentyl group for phosphate/thiophosphate protection. Post-synthesis removal of the protecting group is easily and rapidly achieved under mild conditions at ambient temperature using either pressurized gaseous amines or concentrated ammonium hydroxide.

Ester exchange reaction of oxyphosphorane with thymidine

Ester exchange reaction of oxyphosphorane (1) with thymidine (2) afforded diastereomeric spirooxyphosphoranes 3 under mild conditions in good yield. After hydrolysis, thymidine phosphates monomers (5,6) and dimer (7) were obtained.

Oxidation and reduction of the 5-(2-Deoxyuridinyl)methyl radical

Sleeping beauty: The 5-(2-Deoxyuridinyl)methyl radical 1 is a key intermediate in the thymine oxidative reaction mediated by reactive oxygen species. Evidence is presented that 1 is prone to both oxidation and reduction reactions at the absence of O2. These results question the current paradigm and suggest that the redox chemistry of 1, which has been largely overlooked in the past, may play a major role in determining the fate of 1. Copyright

OLIGONUCLEOTIDES AND NUCLEOTIDOPEPTIDES. XLII. EFFICACY OF THE INTRAMOLECULAR INFLUENCE OF THE CARBOXY GROUPS OF AMINO ACIDS IN NUCLEOTIDYL-(P-->N)-AMINO ACIDS (PEPTIDES) AS A FUNCTION OF THEIR POSITIONS

It has been established that remote carboxy groups in nucleotidyl-(5'-->N)-β-alanine and -alanylalanine do not affect the mechanism of the cleavage of the phosphoramide center.The situation is different in the case of nucleotidyl-(5'-->Nε)-lysine.It has been shown that in the 3'-phenylalanine derivative of dTMP, the influence of the α-carboxy group of the amino acid is only half as great as in the 5'-analog.The α-carboxy groups of the amino acids in oligonucleotidyl-(Pin-->N)-amino acids also weaken the mechanism of the cleavage of the phosphoramide centers.