(R)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine

Base Information

• Chemical Name: (R)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine
• CAS No.: 1339232-03-9
• Molecular Formula: C₁₉H₃₅NO₃Si
• Molecular Weight: 353.577
• Mol file: 1339232-03-9.mol

Synonyms:

Chemical Property of (R)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine

There total 5 articles about (R)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H14O4 → (R)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine (1339232-03-9) + (S)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 18 h / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 90 h / 20 °C / Inert atmosphere

3: hydrazine / ethanol; water / 2 h / Inert atmosphere; Reflux

With 1H-imidazole; di-isopropyl azodicarboxylate; triphenylphosphine; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; water; 2: Mitsunobu reaction;

DOI:10.1039/c1cc13992d

Reference yield:

(S)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanol (1339232-58-4) → (R)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine (1339232-03-9) + (S)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine

Guidance literature:

Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 90 h / 20 °C / Inert atmosphere

2: hydrazine / ethanol; water / 2 h / Inert atmosphere; Reflux

With di-isopropyl azodicarboxylate; triphenylphosphine; hydrazine; In tetrahydrofuran; ethanol; water; 1: Mitsunobu reaction;

DOI:10.1039/c1cc13992d

Reference yield:

(R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione (1339232-59-5) → (R)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine (1339232-03-9) + (S)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanamine

Guidance literature:

With hydrazine; In ethanol; water; for 2h; optical yield given as %ee; Inert atmosphere; Reflux;

DOI:10.1039/c1cc13992d

upstream raw materials:

(S)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanol

(R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione

3,5-dimethoxybenzaldehdye

3,5-dimethoxystyrene

Refernces