(R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione

Base Information

Chemical Name:(R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione
CAS No.:1339232-59-5
Molecular Formula:C₂₇H₃₇NO₅Si
Molecular Weight:483.68
Hs Code.:

Synonyms:(R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione

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Technology Process of (R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione

There total 3 articles about (R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 136918-14-4,85-41-6
phthalimide

: 1339232-58-4
(S)-1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethanol

: 1339232-59-5
(R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 90h; Inert atmosphere;
DOI:10.1039/c1cc13992d

Reference yield:

: C₁₀H₁₄O₄

: 1339232-59-5
(R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 18 h / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 90 h / 20 °C / Inert atmosphere

With 1H-imidazole; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1039/c1cc13992d

Reference yield:

: 40243-87-6
3,5-dimethoxystyrene

: 1339232-59-5
(R)-2-(1-(3,5-dimethoxyphenyl)-2-((triisopropylsilyl)oxy)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: AD-mix-α; water / tert-butyl alcohol / 16 h / 0 °C / Inert atmosphere

2: 1H-imidazole / dichloromethane / 18 h / 20 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 90 h / 20 °C / Inert atmosphere

With 1H-imidazole; AD-mix-α; di-isopropyl azodicarboxylate; water; triphenylphosphine; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 1: Sharpless dihydroxylation / 3: Mitsunobu reaction;
DOI:10.1039/c1cc13992d