Technology Process of 8-(1-{2-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-3,7-dihydropurine-2,6-dione
There total 12 articles about 8-(1-{2-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]ethyl}-1H-pyrazol-4-yl)-1,3-dipropyl-3,7-dihydropurine-2,6-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 2.5 h / 120 - 130 °C / Sealed tube
1.2: 0.33 h / Sealed tube
2.1: thionyl chloride / 2 h / 55 - 60 °C
3.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C
4.1: triethylamine / dichloromethane / 0.25 h / 0 °C
4.2: 1.5 h / 10 - 15 °C
5.1: N,N-dimethyl-formamide / 20 h / 50 - 55 °C
6.1: sodium hydroxide / ethanol; water / 3 h / Reflux
7.1: thionyl chloride / 2 h / 55 - 60 °C
8.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C
9.1: triethylamine / dichloromethane / 0.25 h / 0 °C
9.2: 1.5 h / 10 - 15 °C
10.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C
11.1: hydrogenchloride / ethanol; water / 3 h / Reflux
With
hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium carbonate; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: thionyl chloride / 2 h / 55 - 60 °C
2.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C
3.1: triethylamine / dichloromethane / 0.25 h / 0 °C
3.2: 1.5 h / 10 - 15 °C
4.1: N,N-dimethyl-formamide / 20 h / 50 - 55 °C
5.1: sodium hydroxide / ethanol; water / 3 h / Reflux
6.1: thionyl chloride / 2 h / 55 - 60 °C
7.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C
8.1: triethylamine / dichloromethane / 0.25 h / 0 °C
8.2: 1.5 h / 10 - 15 °C
9.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C
10.1: hydrogenchloride / ethanol; water / 3 h / Reflux
With
hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium carbonate; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / ethanol; water / 3 h / Reflux
2.1: thionyl chloride / 2 h / 55 - 60 °C
3.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C
4.1: triethylamine / dichloromethane / 0.25 h / 0 °C
4.2: 1.5 h / 10 - 15 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C
6.1: hydrogenchloride / ethanol; water / 3 h / Reflux
With
hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium carbonate; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007
