[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid methyl ester

Base Information

Chemical Name:[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid methyl ester
CAS No.:1188542-97-3
Molecular Formula:C₁₄H₁₄F₃NO₃
Molecular Weight:301.265
Hs Code.:

Synonyms:[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid methyl ester

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Chemical Property of [5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid methyl ester

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Technology Process of [5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid methyl ester

There total 7 articles about [5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 1188542-96-2
[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid

: 1188542-97-3
[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid methyl ester

Guidance literature:: With thionyl chloride; at 55 - 60 ℃; for 2h;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 1188542-94-0
[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetonitrile

: 1188542-97-3
[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 3 h / Reflux

2: thionyl chloride / 2 h / 55 - 60 °C

With thionyl chloride; sodium hydroxide; In ethanol; water;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 1188542-97-3
[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-yl]acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2.5 h / 120 - 130 °C / Sealed tube

1.2: 0.33 h / Sealed tube

2.1: thionyl chloride / 2 h / 55 - 60 °C

3.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C

4.1: triethylamine / dichloromethane / 0.25 h / 0 °C

4.2: 1.5 h / 10 - 15 °C

5.1: N,N-dimethyl-formamide / 20 h / 50 - 55 °C

6.1: sodium hydroxide / ethanol; water / 3 h / Reflux

7.1: thionyl chloride / 2 h / 55 - 60 °C

With sodium tetrahydroborate; thionyl chloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007