C₂₅H₃₁Cl₂NO₂S

Base Information

Chemical Name:C₂₅H₃₁Cl₂NO₂S
CAS No.:1574556-44-7
Molecular Formula:C₂₅H₃₁Cl₂NO₂S
Molecular Weight:480.499
Hs Code.:

C<sub>25</sub>H<sub>31</sub>Cl<sub>2</sub>NO<sub>2</sub>S

Synonyms:

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Chemical Property of C₂₅H₃₁Cl₂NO₂S

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Technology Process of C₂₅H₃₁Cl₂NO₂S

There total 12 articles about C₂₅H₃₁Cl₂NO₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rac-(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

: 1574556-44-7
C₂₅H₃₁Cl₂NO₂S

: 1574556-45-8
C₂₅H₃₁Cl₂NO₂S

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

3.1: ytterbium(III) triflate / acetonitrile / 3 h / 130 °C / Microwave irradiation; Inert atmosphere

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

5.1: indium(III) chloride / dichloromethane / 12 h / 25 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

7.1: sodium hydride / tetrahydrofuran; mineral oil / 12 h / 25 °C / Inert atmosphere

8.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 25 °C / Inert atmosphere

9.1: lithium hexamethyldisilazane / 1 h / -78 °C / Inert atmosphere

With 1H-imidazole; indium(III) chloride; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; lithium hexamethyldisilazane; ytterbium(III) triflate; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; 4.1: |Mitsunobu Displacement;
DOI:10.1021/jm401767k

Reference yield:

: C₂₀H₂₅Cl₂NO₃Si

: 1574556-44-7
C₂₅H₃₁Cl₂NO₂S

: 1574556-45-8
C₂₅H₃₁Cl₂NO₂S

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride; zinc / water / Inert atmosphere

2.1: sodium hydroxide / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

4.1: ytterbium(III) triflate / acetonitrile / 3 h / 130 °C / Microwave irradiation; Inert atmosphere

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

6.1: indium(III) chloride / dichloromethane / 12 h / 25 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

8.1: sodium hydride / tetrahydrofuran; mineral oil / 12 h / 25 °C / Inert atmosphere

9.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 25 °C / Inert atmosphere

10.1: lithium hexamethyldisilazane / 1 h / -78 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; indium(III) chloride; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; lithium hexamethyldisilazane; ytterbium(III) triflate; zinc; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 5.1: |Mitsunobu Displacement;
DOI:10.1021/jm401767k

Reference yield:

: 1429387-88-1
(1R,2R)-2-((tert-butyldimethylsilyl)oxy)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethanamine

: 1574556-44-7
C₂₅H₃₁Cl₂NO₂S

: 1574556-45-8
C₂₅H₃₁Cl₂NO₂S

Guidance literature:: Multi-step reaction with 7 steps

1: ytterbium(III) triflate / acetonitrile / 3 h / 130 °C / Microwave irradiation; Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

3: indium(III) chloride / dichloromethane / 12 h / 25 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

5: sodium hydride / tetrahydrofuran; mineral oil / 12 h / 25 °C / Inert atmosphere

6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 25 °C / Inert atmosphere

7: lithium hexamethyldisilazane / 1 h / -78 °C / Inert atmosphere

With indium(III) chloride; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hexamethyldisilazane; ytterbium(III) triflate; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; 2: |Mitsunobu Displacement;
DOI:10.1021/jm401767k