1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester

Base Information

• Chemical Name: 1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester
• CAS No.: 140947-23-5
• Molecular Formula: C20H21NO5
• Molecular Weight: 355.39
• Mol file: 140947-23-5.mol

Synonyms:diethyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylate;

Chemical Property of 1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester

Chemical Property:

• PSA: 74.60000
• LogP: 2.48680

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester

There total 24 articles about 1H-Pyrrolizine-1,1-dicarboxylic acid, 5-benzoyl-2,3-dihydro-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%

C20H23ClO7 → diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate (140947-23-5)

Guidance literature:

With ammonia; In methanol; at 60 ℃; Reagent/catalyst; Temperature; Solvent; Autoclave;

Reference yield: 96.0%

1-(3,3-diethoxycarbonylpropyl)-2-benzoylpyrrole (141031-78-9) → diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate (140947-23-5)

Guidance literature:

With sodium acetate; manganese triacetate; In acetic acid; at 80 ℃; for 6h;

DOI:10.1139/v92-228

Reference yield: 94.2%

phenyl(1H-pyrrol-2-yl)methanone (7697-46-3) + methanetricarboxylic acid triethyl ester (6279-86-3) + acetic anhydride (108-24-7) → diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate (140947-23-5)

Guidance literature:

With sodium acetate; manganese(III) triacetate dihydrate; sodium hydrogensulfite; In water; toluene; Solvent;

upstream raw materials:

1-(3,3-diethoxycarbonyl-3-bromopropyl)-2-benzoylpyrrole

1-(3,3-diethoxycarbonylpropyl)-2-benzoylpyrrole

triethyl (5-benzoylpyrrol-2-yl)-methanetricarboxylate

1,2-dichloro-ethane

Downstream raw materials:

Ketorolac