1-{1-[(2,5-dibromothiophen-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl}ethanone

Base Information

Chemical Name:1-{1-[(2,5-dibromothiophen-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl}ethanone
CAS No.:77626-88-1
Molecular Formula:C₁₈H₁₉Br₂NO₃S
Molecular Weight:489.228
Hs Code.:

Synonyms:Isoquinoline,2-acetyl-1-[(2,5-dibromo-3-thienyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-(9CI); NSC 345776

Suppliers and Price of 1-{1-[(2,5-dibromothiophen-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl}ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 1-{1-[(2,5-dibromothiophen-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl}ethanone

Chemical Property:

Vapor Pressure:4.18E-13mmHg at 25°C
Boiling Point:572.3°Cat760mmHg
Flash Point:299.9°C
Density:1.594g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-{1-[(2,5-dibromothiophen-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl}ethanone

There total 5 articles about 1-{1-[(2,5-dibromothiophen-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-24-7
acetic anhydride

: 77014-16-5
1-(2',5'-dibromo-3'-thenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 77626-88-1
1-(2',5'-dibromo-3'-thenyl)-2-acetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With pyridine; for 1h; Heating;

Reference yield:

: 6964-21-2
thiophen-3-yl-acetic acid

: 77626-88-1
1-(2',5'-dibromo-3'-thenyl)-2-acetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / bromine / acetic acid / 2 h / Ambient temperature

2: 70 percent / 2 h / 150 - 160 °C

3: 85 percent / phosphorus pentachloride / CHCl₃ / 5 h / Ambient temperature

4: 95 percent / sodium borohydride / methanol / 2 h

5: 80 percent / pyridine / 1 h / Heating

With pyridine; sodium tetrahydroborate; phosphorus pentachloride; bromine; In methanol; chloroform; acetic acid;

Reference yield:

: 77014-10-9
2-(2,5-dibromo-thiophen-3-yl)acetic acid

: 77626-88-1
1-(2',5'-dibromo-3'-thenyl)-2-acetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / 2 h / 150 - 160 °C

2: 85 percent / phosphorus pentachloride / CHCl₃ / 5 h / Ambient temperature

3: 95 percent / sodium borohydride / methanol / 2 h

4: 80 percent / pyridine / 1 h / Heating

With pyridine; sodium tetrahydroborate; phosphorus pentachloride; In methanol; chloroform;