Quinoline, 7-bromo-4-methyl-

Base Information

• Chemical Name: Quinoline, 7-bromo-4-methyl-
• CAS No.: 141052-31-5
• Molecular Formula: C10H8BrN
• Molecular Weight: 222.08100
• Hs Code.: 2933499090
• Mol file: 141052-31-5.mol

Synonyms:7-bromo-4-methylquinoline;

Chemical Property of Quinoline, 7-bromo-4-methyl-

Chemical Property:

• Boiling Point: 315.8±22.0 °C(Predicted)
• PKA: 4.08±0.27(Predicted)
• PSA: 12.89000
• Density: 1.488±0.06 g/cm3(Predicted)
• LogP: 3.30570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

7-Bromo-4-methylquinoline 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 7-bromo-4-methyl-

There total 3 articles about Quinoline, 7-bromo-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

methyl vinyl ketone (78-94-4,25038-87-3) + m-Bromoaniline (591-19-5) → 7-bromo-4-methylquinoline (141052-31-5)

Guidance literature:

With iron(III) chloride hexahydrate; In acetic acid; for 3h; Reflux;

DOI:10.1021/acs.jmedchem.7b00259

Reference yield: 43.0%

methyl vinyl ketone (78-94-4,25038-87-3) → 7-bromo-4-methylquinoline (141052-31-5)

Guidance literature:

m-Bromoaniline; With sulfuric acid; In 1,4-dioxane; at 20 ℃;

methyl vinyl ketone; In 1,4-dioxane; for 3h; Heating / reflux;

for 1h; Heating / reflux;

Reference yield:

→ 7-bromo-4-methylquinoline (141052-31-5)

Guidance literature:

upstream raw materials:

methyl vinyl ketone

m-Bromoaniline

Refernces

• 1、 Cinelli, Maris A.,Li, Huiying,Chreifi, Georges,Poulos, Thomas L.,Silverman, Richard B.. "Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors". . p. 3958 - 3978. Retrieved 2017/05/19.
• 2、 -. "NOVEL CYCLIC COMPOUND HAVING QUINOLYLALKYLTHIO GROUP". Page/Page column 13-14. . Retrieved 2010/11/28.