(R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-methyl ester

Base Information

• Chemical Name: (R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-methyl ester
• CAS No.: 1053705-19-3
• Molecular Formula: C₃₉H₄₀N₃O₈PS
• Molecular Weight: 741.802

Synonyms:

Chemical Property of (R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-methyl ester

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of (R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-methyl ester

There total 1 articles about (R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) + methylphosphonothioic dichloride (676-98-2) → (R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-methyl ester (1053705-19-3) + (S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-methyl ester (1053637-70-9)

Guidance literature:

With pyridine; Multistep reaction; 1.) 55 deg C, 15 min, 2.) room temperature, 30 min;

DOI:10.1021/jo981304v

Reference yield:

(R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-methyl ester (1053705-19-3) → (R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester (197578-18-0)

Guidance literature:

Yield given;

DOI:10.1021/jo981304v

Reference yield:

(R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester O-methyl ester (1053705-19-3) → (S)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S-methyl ester

Guidance literature:

Multi-step reaction with 2 steps

2: 90 percent

DOI:10.1021/jo981304v

upstream raw materials:

methanol

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

methylphosphonothioic dichloride

Downstream raw materials:

(R)-Methyl-phosphonothioic acid O-{(2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester

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