erythro-3-hydroxy-4-phenylpentanenitrile

Base Information

• Chemical Name: erythro-3-hydroxy-4-phenylpentanenitrile
• CAS No.: 103108-40-3
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol file: 103108-40-3.mol

Synonyms:

Chemical Property of erythro-3-hydroxy-4-phenylpentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-3-hydroxy-4-phenylpentanenitrile

There total 4 articles about erythro-3-hydroxy-4-phenylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Phenylpropanal (34713-70-7) + cyanomethyl bromide (590-17-0) → threo-3-hydroxy-4-phenylpentanenitrile (103108-40-3,103108-41-4) + erythro-3-hydroxy-4-phenylpentanenitrile (103108-40-3,103108-41-4)

Guidance literature:

With indium; chloro-trimethyl-silane; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1246/bcsj.67.1126

Reference yield:

2-Phenylpropanal (34713-70-7) + cyanomethyl bromide (590-17-0) → threo-3-hydroxy-4-phenylpentanenitrile (103108-40-3,103108-41-4) + erythro-3-hydroxy-4-phenylpentanenitrile (103108-40-3,103108-41-4)

Guidance literature:

With indium; chloro-trimethyl-silane; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1246/bcsj.67.1126

Reference yield:

2-Phenylpropanal (34713-70-7) + acetonitrile (75-05-8,26809-02-9) → threo-3-hydroxy-4-phenylpentanenitrile (103108-40-3,103108-41-4) + erythro-3-hydroxy-4-phenylpentanenitrile (103108-40-3,103108-41-4)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, ether, -78 deg C, 30 min; 2.) THF, ether, -195 deg C, 30 min, from -195 deg C to -120 deg C, 30 min;

DOI:10.1016/S0040-4020(01)96754-7

upstream raw materials:

2-Phenylpropanal

acetonitrile

cyanomethyl bromide