2-Fluoro-4-(methoxymethoxy)-1-nitrobenzene

Base Information

• Chemical Name: 2-Fluoro-4-(methoxymethoxy)-1-nitrobenzene
• CAS No.: 141097-09-8
• Molecular Formula: C8H8FNO4
• Molecular Weight: 201.154
• DSSTox Substance ID: DTXSID70601381
• Nikkaji Number: J1.094.428G
• Wikidata: Q82498008
• Mol file: 141097-09-8.mol

Synonyms:2-fluoro-4-(methoxymethoxy)-1-nitrobenzene;141097-09-8;SCHEMBL564684;DTXSID70601381;WTPHIMOJMXWEAB-UHFFFAOYSA-N;AKOS018840009

Chemical Property of 2-Fluoro-4-(methoxymethoxy)-1-nitrobenzene

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 201.04373590
• Heavy Atom Count: 14
• Complexity: 196

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=CC(=C(C=C1)[N+](=O)[O-])F

Technology Process of 2-Fluoro-4-(methoxymethoxy)-1-nitrobenzene

There total 2 articles about 2-Fluoro-4-(methoxymethoxy)-1-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-fluoro-4-nitrophenol (394-41-2) + chloromethyl methyl ether (107-30-2) → 2-fluoro-4-(methoxymethoxy)-1-nitrobenzene (141097-09-8)

Guidance literature:

3-fluoro-4-nitrophenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h; Cooling with ice;

chloromethyl methyl ether; In N,N-dimethyl-formamide; mineral oil; for 1h;

Reference yield:

Dimethoxymethane (109-87-5) + 3-fluoro-4-nitrophenol (394-41-2) → 2-fluoro-4-(methoxymethoxy)-1-nitrobenzene (141097-09-8)

Guidance literature:

With sodium hydroxide; trichlorophosphate; In N,N-dimethyl-formamide; toluene;

Reference yield: 94.0%

2-fluoro-4-(methoxymethoxy)-1-nitrobenzene (141097-09-8) + tert-butyl alcohol (75-65-0) → 2-tert-butoxy-4-methoxymethoxy-1-nitro-benzene

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at 0 - 23 ℃; for 2h;

DOI:10.1021/jo981647t

upstream raw materials:

Dimethoxymethane

3-fluoro-4-nitrophenol

chloromethyl methyl ether

Downstream raw materials:

2-Fluoro-4-(methoxymethoxy)aniline

4-nitro-3-(tetrahydro-2H-pyran-4-yloxy)phenol

5-(methylsulfonyl)-2-[4-nitro-3-(tetrahydro-2H-pyran-4-yloxy)phenoxy]pyridine

4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

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