4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

Base Information

Chemical Name:4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline
CAS No.:1233540-79-8
Molecular Formula:C₁₇H₂₀N₂O₅S
Molecular Weight:364.422
Hs Code.:

Synonyms:4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

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Chemical Property of 4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

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Technology Process of 4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

There total 5 articles about 4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1233540-78-7
5-(methylsulfonyl)-2-[4-nitro-3-(tetrahydro-2H-pyran-4-yloxy)phenoxy]pyridine

: 1233540-79-8
4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

Guidance literature:: With water; iron; calcium chloride; In ethanol; at 80 ℃; for 4h;

Reference yield:

: 343262-51-1
2-bromo-5-methanesulfonylpyridine

: 1233540-79-8
4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 100 °C

2: water; calcium chloride; iron / ethanol / 4 h / 80 °C

With water; iron; caesium carbonate; calcium chloride; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 394-41-2
3-fluoro-4-nitrophenol

: 1233540-79-8
4-{[5-(Methylsulfonyl)pyridin-2-yl]oxy}-2-(tetrahydro-2H-pyran-4-yloxy)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 1 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

2.2: 4 h / 120 °C

2.3: 2 h / 10 - 35 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 100 °C

4.1: water; calcium chloride; iron / ethanol / 4 h / 80 °C

With water; iron; sodium hydride; caesium carbonate; calcium chloride; In ethanol; N,N-dimethyl-formamide; mineral oil;