Methyl 2-chloropyrimidine-5-carboxylate

Base Information

Chemical Name:Methyl 2-chloropyrimidine-5-carboxylate
CAS No.:287714-35-6
Molecular Formula:C6H5ClN2O2
Molecular Weight:172.571
Hs Code.:2933599090
European Community (EC) Number:822-651-7
DSSTox Substance ID:DTXSID20504873
Wikidata:Q72489435
Mol file:287714-35-6.mol

Synonyms:methyl 2-chloropyrimidine-5-carboxylate;287714-35-6;5-PYRIMIDINECARBOXYLIC ACID, 2-CHLORO-, METHYL ESTER;MFCD08690330;2-CHLOROPYRIMIDINE-5-CARBOXYLIC ACID METHYL ESTER;SCHEMBL63531;2-chloro-5-carbomethoxypyrimidine;DTXSID20504873;VJOKXLBQCKCWLV-UHFFFAOYSA-N;AKOS006283206;CS-W018560;PB17570;methyl 2-chloro-5-pyrimidinecarboxylate;methyl-2-chloropyrimidine-5-carboxylate;DS-10574;SY019433;FT-0648524;EN300-206582;2-chloro-pyrimidine-5-carboxylic acid methyl ester;A819584;Z1198180929

Suppliers and Price of Methyl 2-chloropyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl2-Chloropyrimidine-5-carboxylate
1g
$ 155.00

SynQuest Laboratories
Methyl 2-chloropyrimidine-5-carboxylate 98%
5 g
$ 750.00

SynQuest Laboratories
Methyl 2-chloropyrimidine-5-carboxylate 98%
1 g
$ 225.00

Matrix Scientific
Methyl 2-chloropyrimidine-5-carboxylate 95+%
1g
$ 99.00

Matrix Scientific
Methyl 2-chloropyrimidine-5-carboxylate 95+%
5g
$ 298.00

Matrix Scientific
Methyl 2-chloropyrimidine-5-carboxylate 95+%
10g
$ 510.00

Crysdot
Methyl2-chloropyrimidine-5-carboxylate 98%
25g
$ 594.00

Chemenu
methyl2-chloropyrimidine-5-carboxylate 97%
5g
$ 210.00

Chemenu
methyl2-chloropyrimidine-5-carboxylate 97%
10g
$ 330.00

Chemenu
methyl2-chloropyrimidine-5-carboxylate 97%
25g
$ 660.00

Total 69 raw suppliers

Chemical Property of Methyl 2-chloropyrimidine-5-carboxylate

Chemical Property:

Appearance/Colour:White to off-white powder
Vapor Pressure:0.000883mmHg at 25°C
Melting Point:76 °C
Refractive Index:1.534
Boiling Point:242.8 °C at 760 mmHg
PKA:-3.14±0.22(Predicted)
Flash Point:100.6 °C
PSA：52.08000
Density:1.372 g/cm³
LogP:0.91660
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:172.0039551
Heavy Atom Count:11
Complexity:146

Purity/Quality:

99%, ^*data from raw suppliers

Methyl2-Chloropyrimidine-5-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/21/22-36/37/38
Safety Statements: 22-26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CN=C(N=C1)Cl
Uses Methyl 2-Chloropyrimidine-5-carboxylate could be useful the preparation of ACSS2 inhibitors, which are have anti-inflammatory and anti-depressant activity.

Technology Process of Methyl 2-chloropyrimidine-5-carboxylate

There total 4 articles about Methyl 2-chloropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.4%

: 308348-93-8
2-amino-pyrimidine-5-carboxylic acid methyl ester

: 287714-35-6
2-chloro-pyrimidine-5-carboxylic acid methyl ester

Guidance literature:: 2-amino-pyrimidine-5-carboxylic acid methyl ester; With hydrogenchloride; zinc(II) chloride; In dichloromethane; at 5 - 20 ℃; for 0.5h;

With sodium nitrite; at 5 - 10 ℃; for 2h;