N-(5-bromopyridin-2-yl)-2-chloroacetamide

Base Information

• Chemical Name: N-(5-bromopyridin-2-yl)-2-chloroacetamide
• CAS No.: 141454-61-7
• Molecular Formula: C7H6BrClN2O
• Molecular Weight: 249.494
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90428552
• Wikidata: Q72512068
• Mol file: 141454-61-7.mol

Synonyms:N-(5-bromopyridin-2-yl)-2-chloroacetamide;141454-61-7;N-(5-bromo-2-pyridinyl)-2-chloroacetamide;acetamide,n-(5-bromo-2-pyridinyl)-2-chloro-;SCHEMBL2319444;DTXSID90428552;OVIDBGFJVRQUPX-UHFFFAOYSA-N;MFCD00461174;STK205651;AKOS000268696;LS-01178;CS-0215427;FT-0770297;EN300-24663;AN-584/40403444;Z199472018

Chemical Property of N-(5-bromopyridin-2-yl)-2-chloroacetamide

Chemical Property:

• Vapor Pressure: 9.5E-07mmHg at 25°C
• Boiling Point: 404.4oC at 760 mmHg
• Flash Point: 198.4oC
• PSA: 41.99000
• Density: 1.74g/cm3
• LogP: 2.09440
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 247.93520
• Heavy Atom Count: 12
• Complexity: 168

Purity/Quality:

98%min ^*data from raw suppliers

N-(5-Bromopyridin-2-yl)-2-chloroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1Br)NC(=O)CCl

Technology Process of N-(5-bromopyridin-2-yl)-2-chloroacetamide

There total 1 articles about N-(5-bromopyridin-2-yl)-2-chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5-bromo-2-pyridylamine (1072-97-5) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(2-(5-bromo)pyridinyl)acetamide (141454-61-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 17h;

DOI:10.1016/S0968-0896(03)00225-6

Reference yield: 96.0%

5-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazole-2(3H)-thione + 2-chloro-N-(2-(5-bromo)pyridinyl)acetamide (141454-61-7) → N-(5-bromopyridin-2-yl)-2-{[5-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]thio}acetamide

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

DOI:10.1007/s11164-015-2170-7

Reference yield: 83.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 2-chloro-N-(2-(5-bromo)pyridinyl)acetamide (141454-61-7) → 2-(1-(4-(2-methoxyphenyl)piperazinyl))-N-(2-(5-bromo)pyridinyl)acetamide (345966-45-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

DOI:10.1016/S0968-0896(03)00225-6

upstream raw materials:

5-bromo-2-pyridylamine

chloroacetyl chloride

Downstream raw materials:

2-(1-(4-(2-methoxyphenyl)piperazinyl))-N-(2-(5-bromo)pyridinyl)acetamide

N-(2-(2-(5-bromopyridin-2-ylamino)-2-oxoethylthio)benzo[d]thiazol-6-yl)-2-methoxybenzamide

C₁₆H₁₀BrCl₂N₅O₂S₂

C₁₇H₁₄BrN₅O₃S₂

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