3-Ethyl-2-methylpyridine

Base Information

• Chemical Name: 3-Ethyl-2-methylpyridine
• CAS No.: 14159-59-2
• Molecular Formula: C8H11N
• Molecular Weight: 121.182
• UNII: 8S6IRA9M3N
• DSSTox Substance ID: DTXSID0074841
• Nikkaji Number: J38.335J
• Wikidata: Q27270955
• Mol file: 14159-59-2.mol

Synonyms:3-ethyl-2-methylpyridine;14159-59-2;27987-10-6;ethylmethylpyridine;2-methyl-3-ethylpyridine;METHYLETHYLPYRIDINE;Pyridine, ethylmethyl-;Pyridine, 3-ethyl-2-methyl-;UNII-8S6IRA9M3N;8S6IRA9M3N;3-ethyl-2-picoline;Pyridine,ethylmethyl-;3-ethyl-2-methyl-pyridine;SCHEMBL487765;2-PICOLINE, 3-ETHYL-;DTXSID0074841;ZZKDGABMFBCSRP-UHFFFAOYSA-N;AMY17406;MFCD00137530;AKOS006274915;CS-0090913;FT-0726069;Q27270955;Ethyl eneglycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid

Chemical Property of 3-Ethyl-2-methylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 1.95240
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 121.089149355
• Heavy Atom Count: 9
• Complexity: 80.6

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-Ethyl-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(N=CC=C1)C

Technology Process of 3-Ethyl-2-methylpyridine

There total 12 articles about 3-Ethyl-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-chloro-5-ethyl-6-methyl-2,3,4,5-tetrahydropyridine (326893-29-2) → 2-methyl-3-ethyl-pyridine (14159-59-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; Heating;

DOI:10.1021/jo000724t

Reference yield: 51.1%

2-methyl-3-((trimethylsilyl)ethynyl)pyridine (913696-56-7) → 2-methyl-3-ethyl-pyridine (14159-59-2)

Guidance literature:

2-methyl-3-((trimethylsilyl)ethynyl)pyridine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogen; palladium 10% on activated carbon; at 20 ℃; for 6h;

Reference yield:

2-Pentanone (107-87-9) + Trimethylenediamine (109-76-2,54018-94-9) → 2-propylpyridine (622-39-9) + 2-methyl-3-ethyl-pyridine (14159-59-2)

Guidance literature:

With oxygen; copper diacetate; palladium diacetate; In dimethyl sulfoxide; at 120 ℃; for 15h; under 760.051 Torr; Overall yield = 13 %;

DOI:10.3987/COM-18-S(F)45

upstream raw materials:

1-(2-methylpyridin-3-yl)ethanone

4,6-dichloro-3-ethyl-2-methyl-pyridine

2-Pentanone

allyl alcohol

Downstream raw materials:

3-ethylpicolinic acid

3-ethyl-2-pyridinecarbonitrile

Refernces

• 1、 -. "Benzimidazole compound". Page/Page column 74. . Retrieved 2008/06/13.
• 2、 Aelterman,De Kimpe,Tyvorskii,Kulinkovich. "Synthesis of 2,3-disubstituted pyrroles and pyridines from 3-halo-1-azaallylic anions". . p. 53 - 58. Retrieved 2007/10/03.