2,4-dichloro-3-fluoro-phenol

Base Information

• Chemical Name: 2,4-dichloro-3-fluoro-phenol
• CAS No.: 343-99-7
• Molecular Formula: C₆H₃Cl₂FO
• Molecular Weight: 180.994
• Mol file: 343-99-7.mol

Synonyms:

Chemical Property of 2,4-dichloro-3-fluoro-phenol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dichloro-3-fluoro-phenol

There total 4 articles about 2,4-dichloro-3-fluoro-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-3-fluoroaniline (443-93-6) → 2,4-dichloro-3-fluoro-phenol (343-99-7)

Guidance literature:

With sulfuric acid; sodium nitrite; Eintragen des Reaktionsgemisches in heisse wss. Kupfer(II)-sulfat-Loesung unter Durchleiten von Wasserdampf;

Reference yield:

1,3-dichloro-2-fluorobenzene (2268-05-5) → 2,4-dichloro-3-fluoro-phenol (343-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid / 60 °C

2: SnCl₂; aqueous HCl

3: sodium nitrite; sulfuric acid / Eintragen des Reaktionsgemisches in heisse wss. Kupfer(II)-sulfat-Loesung unter Durchleiten von Wasserdampf

With hydrogenchloride; sulfuric acid; nitric acid; tin(ll) chloride; sodium nitrite;

Reference yield:

1,3-dichloro-2-fluoro-4-nitrobenzene (393-79-3) → 2,4-dichloro-3-fluoro-phenol (343-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₂; aqueous HCl

2: sodium nitrite; sulfuric acid / Eintragen des Reaktionsgemisches in heisse wss. Kupfer(II)-sulfat-Loesung unter Durchleiten von Wasserdampf

With hydrogenchloride; sulfuric acid; tin(ll) chloride; sodium nitrite;

upstream raw materials:

2,4-dichloro-3-fluoroaniline

1,3-dichloro-2-fluorobenzene

1,3-dichloro-2-fluoro-4-nitrobenzene

2,6-Dichloroaniline

Downstream raw materials:

(2,4-dichloro-3-fluoro-phenoxy)-acetic acid

Refernces

Synthesis of 10-(Hydroxymethyl)-7,12-dimethylbenzanthracene

10.1021/jo00359a058

The research involves the synthesis of various organic compounds. The first part focuses on the synthesis of a keto ester and a bicyclic keto lactam. The key chemicals used include ketene O,S-acetals, p-TsOH, methylamine, and silica gel for purification. The second part describes the synthesis of 10-(hydroxymethyl)-7,12-dimethylbenz[a]anthracene, involving a series of reactions starting from 1,2-naphthalic anhydride and chlorobenzene, with reagents such as AlCl?, NaBH?, Zn, KOH, and others playing crucial roles. The final part reports the synthesis of gem-dilithiofluorene by thermal rearrangement of 9-lithiofluorene, with n-butyllithium and fluorene as the starting materials. The research highlights the use of various solvents like THF, benzene, and ethyl acetate, and purification techniques such as chromatography and recrystallization.