2,4-Dichloro-3-fluoroaniline

Base Information

• Chemical Name: 2,4-Dichloro-3-fluoroaniline
• CAS No.: 443-93-6
• Molecular Formula: C6H4 Cl2 F N
• Molecular Weight: 180.009
• Hs Code.: 2921420090
• Mol file: 443-93-6.mol

Synonyms:Aniline,2,4-dichloro-3-fluoro- (8CI); 2,4-Dichloro-3-fluoroaniline

Chemical Property of 2,4-Dichloro-3-fluoroaniline

Chemical Property:

• Vapor Pressure: 0.0173mmHg at 25°C
• Refractive Index: 1.587
• Boiling Point: 254.4°Cat760mmHg
• Flash Point: 107.6°C
• PSA: 26.02000
• Density: 1.502g/cm³
• LogP: 3.29590
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%Min ^*data from raw suppliers

2,4-Dichloro-3-fluoroaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dichloro-3-fluoroaniline

There total 3 articles about 2,4-Dichloro-3-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

1,3-dichloro-2-fluoro-4-nitrobenzene (393-79-3) → 2,4-dichloro-3-fluoroaniline (443-93-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 80 ℃; for 2h; under 15001.5 Torr; Temperature; Solvent; Autoclave;

Reference yield:

1,3-dichloro-2-fluorobenzene (2268-05-5) → 2,4-dichloro-3-fluoroaniline (443-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid / 60 °C

2: SnCl₂; aqueous HCl

With hydrogenchloride; nitric acid; tin(ll) chloride;

Reference yield:

2,6-Dichloroaniline (608-31-1) → 2,4-dichloro-3-fluoroaniline (443-93-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous hydrochloric acid; aqueous sodium nitrite solution; aqueous tetrafluoroboric acid / Erhitzen des Reaktionsprodukts auf 235grad

2: nitric acid / 60 °C

3: SnCl₂; aqueous HCl

With hydrogenchloride; tetrafluoroboric acid; nitric acid; tin(ll) chloride; sodium nitrite;

upstream raw materials:

1,3-dichloro-2-fluoro-4-nitrobenzene

1,3-dichloro-2-fluorobenzene

2,6-Dichloroaniline

Downstream raw materials:

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

5-bromo-1,3-dichloro-2-fluorobenzene

(2,4-dichloro-3-fluoro-phenoxy)-acetic acid

2,4-dichloro-3-fluoro-phenol

Refernces