8-Hydroxyrebamipide

Base Information

• Chemical Name: 8-Hydroxyrebamipide
• CAS No.: 109387-73-7
• Molecular Formula: C₁₉H₁₅ClN₂O₅
• Molecular Weight: 386.791
• Mol file: 109387-73-7.mol

Synonyms:

Chemical Property of 8-Hydroxyrebamipide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Hydroxyrebamipide

There total 2 articles about 8-Hydroxyrebamipide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(ω-bromoacetoacetyl)-4-methoxyaniline (20335-27-7) → 8-Hydroxyrebamipide (109387-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium / 1.) EtOH, 1 h; 2.) reflux, 3 h

With sodium;

DOI:10.1248/cpb.34.4821

Reference yield:

4-chloro-benzoyl chloride (122-01-0) + ethyl 2-acetylamino-2-ethoxycarbonyl-3-<8-methoxy-2(1H)-quinolinon-4-yl>propionate (109387-72-6) → 8-Hydroxyrebamipide (109387-73-7)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1248/cpb.34.4821

upstream raw materials:

4-chloro-benzoyl chloride

ethyl 2-acetylamino-2-ethoxycarbonyl-3-<8-methoxy-2(1H)-quinolinon-4-yl>propionate

N-(ω-bromoacetoacetyl)-4-methoxyaniline