4-(DIMETHYLAMINO)-1,1,1-TRIFLUOROBUT-3-EN-2-ONE

Base Information

• Chemical Name: 4-(DIMETHYLAMINO)-1,1,1-TRIFLUOROBUT-3-EN-2-ONE
• CAS No.: 142503-25-1
• Molecular Formula: C6H8F3NO
• Molecular Weight: 167.131
• Hs Code.: 2922498590
• Mol file: 142503-25-1.mol

Synonyms:4-dimethylamino-1,1,1-trifluorobut-3-en-2-one;4-(DIMETHYLAMINO)-1,1,1-TRIFLUOROBUT-3-EN-2-ONE;

Chemical Property of 4-(DIMETHYLAMINO)-1,1,1-TRIFLUOROBUT-3-EN-2-ONE

Chemical Property:

• PSA: 20.31000
• LogP: 1.19310

Purity/Quality:

4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(DIMETHYLAMINO)-1,1,1-TRIFLUOROBUT-3-EN-2-ONE

There total 5 articles about 4-(DIMETHYLAMINO)-1,1,1-TRIFLUOROBUT-3-EN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (59938-06-6) + dimethyl amine (124-40-3) → 4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one (142503-25-1)

Guidance literature:

With water; at 20 ℃;

DOI:10.1055/s-2001-11435

Reference yield: 17.0%

1-dimethylaminomethyl-naphthalen-2-ol (5419-02-3) + 1,1,1-trifluoro-4-(morpholin-4-yl)but-3-en-2-one (428842-08-4) → 2-hydroxy-1-(N-morpholinomethyl)naphthalene (27438-39-7) + 1-(1H-benzo[f]chromen-2-yl)-2,2,2-trifluoroethan-1-one + 3-(trifluoromethyl)-2,3-dihydro-1H-benzo[f]chromen-3-ol + 4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one (142503-25-1)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 5h; Solvent; Reflux;

DOI:10.1021/acs.joc.6b02716

Reference yield:

ethyl vinyl ether (109-92-2,25104-37-4) + trifluoroacetic anhydride (407-25-0) → 4-(dimethylamino)-1,1,1-trifluorobut-3-en-2-one (142503-25-1)

Guidance literature:

ethyl vinyl ether; trifluoroacetic anhydride; dmap; In dichloromethane; at 0 - 20 ℃; for 2.5h;

With dimethyl amine; In dichloromethane; water; at -5 ℃; for 0.166667h;

upstream raw materials:

(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

dimethyl amine

ethyl vinyl ether

trifluoroacetic anhydride

Downstream raw materials:

(E)-4-(4-bromophenyl)-1,1,1-trifluoro-3-buten-2-one

(E)-4-(4-methoxyphenyl)-1,1,1-trifluorobut-3-en-2-one

(E)-1,1,1-trifluoro-7-phenylhept-3-en-2-one

1,1,1-trifluoro-4-phenylbut-3-en-2-one