Phosphinic acid, dimethyl-, methyl ester

Base Information

• Chemical Name: Phosphinic acid, dimethyl-, methyl ester
• CAS No.: 14337-77-0
• Molecular Formula: C3H9O2P
• Molecular Weight: 108.077
• DSSTox Substance ID: DTXSID20470781
• Nikkaji Number: J880.739F
• Wikidata: Q82298952
• Mol file: 14337-77-0.mol

Synonyms:methyl dimethylphosphinate;Phosphinic acid, dimethyl-, methyl ester;14337-77-0;SCHEMBL30845;DTXSID20470781;Dimethyl-phosphinic acid methyl ester

Chemical Property of Phosphinic acid, dimethyl-, methyl ester

Chemical Property:

• XLogP3: -0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 108.03401652
• Heavy Atom Count: 6
• Complexity: 72.9

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COP(=O)(C)C

Technology Process of Phosphinic acid, dimethyl-, methyl ester

There total 3 articles about Phosphinic acid, dimethyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylphosphane (594-09-2) → Trimethylphosphine oxide (676-96-0) + dimethyl-phosphinic acid methyl ester (14337-77-0) + dimethylmethoxyphosphines-d0 (20502-88-9) + dimethyl methane phosphonate (756-79-6)

Guidance literature:

With oxygen; for 48h; Mechanism; also in the presence of 18O₂; variation of partial pressures;

Reference yield:

methyl dimethylphosphinothionate (29952-66-7) → dimethylphosphinic acid (3283-12-3) + dimethyl-phosphinic acid methyl ester (14337-77-0)

Guidance literature:

With sulfuric acid-d2; at 75 ℃; Rate constant; various pH;

DOI:10.1039/c39850000832

Reference yield:

methanol (67-56-1) + N-(2-phenylethyl)-P,P-dimethylphosphinamide (80918-98-5) → dimethyl-phosphinic acid methyl ester (14337-77-0) + 2-phenylethylamine hydrochloride (156-28-5)

Guidance literature:

With hydrogenchloride; Rate constant; Kinetics; Thermodynamic data; E, ΔS, ΔG presented;

upstream raw materials:

methanol

N-(2-phenylethyl)-P,P-dimethylphosphinamide

methyl dimethylphosphinothionate

trimethylphosphane

Downstream raw materials:

dimethylphosphinic acid

dimethyl diphosphonic acid dimethyl ester

benzaldehyde

Refernces

• 1、 Ramage, Robert,Atrash, Butrus,Hopton, David,Parrot, Maxwell J.. "Evaluation of Phosphinic Acid Derivatives as Reagents For Amine Protection in Peptide Synthesis". . p. 1217 - 1226. Retrieved 2007/10/02.