1,2,3,4-Tetrahydro-1,2-dimethylisoquinoline

Base Information

• Chemical Name: 1,2,3,4-Tetrahydro-1,2-dimethylisoquinoline
• CAS No.: 14429-09-5
• Molecular Formula: C11H15N
• Molecular Weight: 161.24300
• Hs Code.: 2933499090
• Mol file: 14429-09-5.mol

Synonyms:1,2,3,4-Tetrahydro-1,2-dimethylisoquinoline;Isoquinoline,1,2,3,4-tetrahydro-1,2-dimethyl;1,2-Dimethyl-1,2,3,4-tetrahydroisoquinoline;

Chemical Property of 1,2,3,4-Tetrahydro-1,2-dimethylisoquinoline

Chemical Property:

• PSA: 3.24000
• LogP: 2.17340

Purity/Quality:

1,2-Dimethyl-1,2,3,4-tetrahydroisoquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-Tetrahydro-1,2-dimethylisoquinoline

There total 21 articles about 1,2,3,4-Tetrahydro-1,2-dimethylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-formyl-1,2,3,4-tetrahydro-1-methylisoquinoline (79011-27-1) → N-methyl-2-methyl-1,2,3,4-tetrahydroisoquinoline (14429-09-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.3987/com-97-s70

Reference yield: 89.0%

2-methyl-3,4-dihydroisoquinolinium cation (92885-35-3) + methylmagnesium bromide (75-16-1) → N-methyl-2-methyl-1,2,3,4-tetrahydroisoquinoline (14429-09-5)

Guidance literature:

In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 0.25h;

DOI:10.1002/ejoc.201701320

Reference yield: 85.0%

methyl magnesium iodide (917-64-6) + 2-methyl-1,2-dihydroisoquinolinium iodide (111783-60-9) → N-methyl-2-methyl-1,2,3,4-tetrahydroisoquinoline (14429-09-5)

Guidance literature:

In diethyl ether; 1.) reflux, 1 h, 2.) 20 deg C, 14 h;

upstream raw materials:

1,2-dimethyl-1,2-dihydroisoquinoline

methyl magnesium iodide

N-methyl-1,2,3,4-tetrahydroisoquinoline N-oxide

2-methyl-1,2-dihydroisoquinolinium iodide

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