3-(4-hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one

Base Information

Chemical Name:3-(4-hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
CAS No.:25205-49-6
Molecular Formula:C16H14 O4
Molecular Weight:270.285
Hs Code.:
Mol file:25205-49-6.mol

Synonyms:Chalcone,2',4-dihydroxy-3-methoxy- (6CI,8CI); 2',4-Dihydroxy-3-methoxychalcone; NSC94615

Suppliers and Price of 3-(4-hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 3-(4-hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one

Chemical Property:

Vapor Pressure:1.99E-09mmHg at 25°C
Boiling Point:469.2°C at 760 mmHg
Flash Point:176.3°C
Density:1.282g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(4-hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one

There total 7 articles about 3-(4-hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 121-33-5,8014-42-4
vanillin

: 104236-73-9,25205-49-6
(2E)-3-(4-hydroxyphenyl-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one

Guidance literature:: With silica gel supported KHSO₄; at 92 - 99 ℃; for 0.1h; under 3975.4 - 4275.43 Torr; Microwave irradiation;
DOI:10.1016/j.tet.2013.11.106

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 121-33-5,8014-42-4
vanillin

: 25205-49-6
2′,4-dihydroxy-3-methoxychalcone

Guidance literature:: o-hydroxyacetophenone; vanillin; With sodium hydroxide; In water; at 20 ℃;

With hydrogenchloride; In water; pH=2;
DOI:10.1016/j.bmcl.2008.10.084

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 104236-73-9,25205-49-6
(2E)-3-(4-hydroxyphenyl-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

2: Ba(OH)2*8H₂O / methanol / 12 h / 40 °C

3: p-TsOH / methanol / 3 h / Ambient temperature

With barium dihydroxide; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jm00076a019