[1,1'-Biphenyl]-2-sulfonamide, N-(1,1-dimethylethyl)-4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin- 3-yl)methyl]-

Base Information

• Chemical Name: [1,1'-Biphenyl]-2-sulfonamide, N-(1,1-dimethylethyl)-4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin- 3-yl)methyl]-
• CAS No.: 145004-88-2
• Molecular Formula: C27H32N4O2S
• Molecular Weight: 476.63400
• Mol file: 145004-88-2.mol

Synonyms:

Chemical Property of [1,1'-Biphenyl]-2-sulfonamide, N-(1,1-dimethylethyl)-4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin- 3-yl)methyl]-

Chemical Property:

• PSA: 85.26000
• LogP: 6.87430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1,1'-Biphenyl]-2-sulfonamide, N-(1,1-dimethylethyl)-4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin- 3-yl)methyl]-

There total 3 articles about [1,1'-Biphenyl]-2-sulfonamide, N-(1,1-dimethylethyl)-4'-[(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin- 3-yl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine (133240-06-9) + [[2'-[(t-Butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl] bromide (138733-52-5) → 4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide (145004-88-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

DOI:10.1021/jm00050a002

Reference yield:

benzenesulfonyl chloride (98-09-9) → 4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide (145004-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / CH₂Cl₂

2: 1.) BuLi, 2.) B(OiPr)3, 3.) NaOH / 3.) Pd(PPh₃)4 / 1.) THF, 2.) THF, 3.) toluene, EtOH, reflux

With sodium hydroxide; n-butyllithium; Triisopropyl borate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane;

DOI:10.1016/0960-894X(96)00017-0

Reference yield:

N-tert-butylbenzenesulfonamide (2512-24-5) + 2-ethyl-5,7-dimethyl-3-(4-bromobenzyl)imidazo<4,5-b>pyridine (154553-72-7) → 4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide (145004-88-2)

Guidance literature:

With sodium hydroxide; n-butyllithium; Triisopropyl borate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Yield given. Multistep reaction; 1.) THF, 2.) THF, 3.) toluene, EtOH, reflux;

DOI:10.1016/0960-894X(96)00017-0

upstream raw materials:

5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine

[[2'-[(t-Butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl] bromide

N-tert-butylbenzenesulfonamide

2-ethyl-5,7-dimethyl-3-(4-bromobenzyl)imidazo<4,5-b>pyridine

Downstream raw materials:

3-<<2'-aminosulfonyl><1,1'-biphenyl-4-yl>-methyl>-5,7-dimethyl-2-ethyl-imidazo<4,5-b>pyridine

MK 996