4-(4-Hydroxy-3-methoxyphenyl)butanoic acid

Base Information

Chemical Name:4-(4-Hydroxy-3-methoxyphenyl)butanoic acid
CAS No.:14563-39-4
Molecular Formula:C11H14O4
Molecular Weight:210.23
Hs Code.:
DSSTox Substance ID:DTXSID10600257
Nikkaji Number:J533.202H
Wikidata:Q82496241
Mol file:14563-39-4.mol

Synonyms:4-(4-hydroxy-3-methoxyphenyl)butanoic acid;14563-39-4;SCHEMBL3175165;DTXSID10600257;4-(4-hydroxy-3-methoxyphenyl)butanoicacid;4-(4-hydroxy-3 methoxyphenyl) butanoic acid;EN300-1857241

Suppliers and Price of 4-(4-Hydroxy-3-methoxyphenyl)butanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-(4-Hydroxy-3-methoxyphenyl)butanoic acid

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:210.08920892
Heavy Atom Count:15
Complexity:205

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)CCCC(=O)O)O

Technology Process of 4-(4-Hydroxy-3-methoxyphenyl)butanoic acid

There total 7 articles about 4-(4-Hydroxy-3-methoxyphenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: benzyl 2-(4-(benzyloxy)-3-methoxyphenyl)cyclopropane-1-carboxylate

: 14563-39-4
4-(4-hydroxy-3-methoxyphenyl)butanoic acid

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; under 760.051 Torr;
DOI:10.1021/acs.jmedchem.1c00644

Reference yield:

: 14335-79-6
5-(4-hydroxy-3-methoxy-phenyl)-dihydro-furan-2-one

: 14563-39-4
4-(4-hydroxy-3-methoxyphenyl)butanoic acid

Guidance literature:: With hydrogen; palladium on barium sulfate; In ethanol;
DOI:10.1002/ardp.19662990614

Reference yield:

: 1135-24-6,537-98-4
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

: 14563-39-4
4-(4-hydroxy-3-methoxyphenyl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C / 760.05 Torr

With palladium on activated charcoal; hydrogen; sodium hydride; potassium carbonate; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.1c00644