tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate

Base Information

Chemical Name:tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate
CAS No.:146651-71-0
Molecular Formula:C9H19NO5
Molecular Weight:221.254
Hs Code.:2924199090
Mol file:146651-71-0.mol

Synonyms:tert-butyl (1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)carbamate;tert-butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamate;N-(tert-butyloxycarbonyl)tris(hydroxymethyl)aminomethane;N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol;N-Boc tris(hydroxymethyl)aminomethane;tert-Butyl N-tris(hydroxymethyl)methylcarbamate;N-(tert-butyloxycarbonyl)-1,1,1-tris(hydroxymethyl)methylamine;

Suppliers and Price of tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate >95%
500mg
$ 295.00

Matrix Scientific
tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate >95%
5g
$ 1400.00

Matrix Scientific
tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate >95%
1g
$ 347.00

Crysdot
tert-ButylN-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate 95+%
1g
$ 344.00

Chemenu
tert-butyl(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)carbamate 95%
1g
$ 325.00

BroadPharm
N-Boc-Tris 99%
25 G
$ 1900.00

BroadPharm
N-Boc-Tris 99%
1 G
$ 380.00

BroadPharm
N-Boc-Tris 99%
5 G
$ 980.00

American Custom Chemicals Corporation
TERT-BUTYL-N-[2-HYDROXY-1,1-BIS(HYDROXYMETHYL)-ETHYL]CARBAMATE 95.00%
5MG
$ 501.38

Ambeed
tert-ButylN-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate 95%
1g
$ 52.00

Total 21 raw suppliers

Chemical Property of tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate

Chemical Property:

Melting Point:144-146 °C(Solv: tetrahydrofuran (109-99-9))
Boiling Point:430.5±45.0 °C(Predicted)
PKA:10.66±0.46(Predicted)
PSA：99.02000
Density:1?+-.0.06 g/cm3(Predicted)
LogP:-0.38230
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description N-Boc-Tris contains an acid labile, Boc protecting group.

Technology Process of tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate

There total 2 articles about tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 146651-71-0
N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol

Guidance literature:: In methanol; at 20 ℃;
DOI:10.1016/j.jfluchem.2006.11.013

Reference yield: 78.0%

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 146651-71-0
N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 2h;
DOI:10.1021/ja00057a015

Reference yield: 100.0%

: 22071-15-4,22161-86-0
ketoprofen

: 146651-71-0
N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol

: Boc-tris(hydroxymethyl)aminomethane-ketoprofen

Guidance literature:: ketoprofen; With triethylamine; dimethylphosphinothioic chloride; In dichloromethane; for 0.166667h; Cooling with ice;

N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol; With dmap; ammonia; triethylamine; In 1,4-dioxane; dichloromethane; water; at 20 ℃; for 0.666667h;