BUTTPARK 121\16-92

Base Information

• Chemical Name: BUTTPARK 121\16-92
• CAS No.: 146944-34-5
• Molecular Formula: C17H26N2O3
• Molecular Weight: 306.405
• Mol file: 146944-34-5.mol

Synonyms:1,1-dimethylethyl {[4-(phenylmethyl)-2-morpholinyl]methyl}carbamate;(4-benzyl-morpholin-2-ylmethyl)-carbamic acid tert-butylester;(4-benzyl-morpholin-2-ylmethyl)-carbamic acid tert-butyl ester;1,1-dimethylethyl {[(2R,S)-4-(phenylmethyl)-2-morpholinyl]methyl}carbamate;4-benzyl-2-(tert-butoxycarbonyl)aminomethylmorpholine;TERT-BUTYL (4-BENZYLMORPHOLIN-2-YL)METHYLCARBAMATE;t-butyl rac-[(4-benzyl-2-morpholinyl)methyl]-carbamate;

Chemical Property of BUTTPARK 121\16-92

Chemical Property:

• Boiling Point: 423.1±25.0 °C(Predicted)
• PKA: 12.22±0.46(Predicted)
• PSA: 50.80000
• Density: 1.083±0.06 g/cm3(Predicted)
• LogP: 2.74090

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl(4-Benzylmorpholin-2-yl)methylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BUTTPARK 121\16-92

There total 6 articles about BUTTPARK 121\16-92 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + (4-benzylmorpholin-2-yl)methanamine (110859-47-7,140646-11-3) → (4-benzylmorpholin-2-ylmethyl)carbamic acid tert-butyl ester (146944-34-5)

Guidance literature:

In acetonitrile; at 25 ℃; for 12h; Product distribution / selectivity;

Reference yield:

N-benzyl-2-chloromethylmorpholine (40987-25-5,186293-54-9) + iminodicarboxylic acid di-tert-butyl ester (51779-32-9) → (4-benzylmorpholin-2-ylmethyl)carbamic acid tert-butyl ester (146944-34-5) + C22H34N2O5

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 140 ℃; Product distribution / selectivity;

Reference yield:

benzaldehyde (100-52-7) → (4-benzylmorpholin-2-ylmethyl)carbamic acid tert-butyl ester (146944-34-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / methanol / 4 h / Reflux

1.2: 1.5 h / 0 - 20 °C

2.1: 12 h / 20 °C

2.2: 1.25 h / 0 - 130 °C

3.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 12 h / 110 °C

4.1: triphenylphosphine / tetrahydrofuran; water / 12 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 4 h / 20 °C

With sodium azide; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

di-tert-butyl dicarbonate

(4-benzylmorpholin-2-yl)methanamine

N-benzyl-2-chloromethylmorpholine

iminodicarboxylic acid di-tert-butyl ester

Downstream raw materials:

1,1-dimethylethyl {[(2R)-4-(phenylmethyl)-2-morpholinyl]methyl}carbamate

1,1-dimethylethyl {[(2S)-4-(phenylmethyl)-2-morpholinyl]methyl}carbamate

N-(morpholin-2-ylmethyl)carbamic acid tert-butyl ester