Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, phenylmethyl ester
• CAS No.: 147269-02-1
• Molecular Formula: C33H42F3N3O5Si
• Molecular Weight: 645.794
• Mol file: 147269-02-1.mol

Synonyms:

Chemical Property of Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, phenylmethyl ester

There total 22 articles about Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide (147313-49-3) → 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide (147269-02-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 6h; under 2550.2 Torr;

DOI:10.1021/jm00046a015

Reference yield:

N-(2-tert-Butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropyl-propyl)-2-iodoacetamide (147269-05-4) + 3-benzyloxycarbonylamino-6-phenylpyrid-2-one (147269-01-0) → 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide (147269-02-1)

Guidance literature:

With NaH; In N-methyl-acetamide; dichloromethane; ethyl acetate;

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide (147269-02-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine / dichloromethane / 12 h

2: sodium iodide / acetone / 12 h / Ambient temperature

3: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

4: hydrogen / palladium on activated charcoal / ethanol / 6 h / 2550.2 Torr

With 2,6-dimethylpyridine; hydrogen; sodium hydride; sodium iodide; palladium on activated charcoal; In ethanol; dichloromethane; acetone;

DOI:10.1021/jm00046a015

upstream raw materials:

N-(2-tert-Butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropyl-propyl)-2-iodoacetamide

3-benzyloxycarbonylamino-6-phenylpyrid-2-one

2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

t-butyldimethylsiyl triflate

Downstream raw materials:

2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

2-(3-Acetylamino-2-oxo-6-phenyl-2H-pyridin-1-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide