Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, (2,6-dimethyl-4-pyridinyl)methyl ester

Base Information Edit

Chemical Name:Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, (2,6-dimethyl-4-pyridinyl)methyl ester
CAS No.:147283-55-4
Molecular Formula:C34H45F3N4O5Si
Molecular Weight:674.836
Hs Code.:
Mol file:147283-55-4.mol

Carbamic acid,
[1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl
ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-,
(2,6-dimethyl-4-pyridinyl)methyl ester

Synonyms:

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Chemical Property of Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, (2,6-dimethyl-4-pyridinyl)methyl ester Edit

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Technology Process of Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, (2,6-dimethyl-4-pyridinyl)methyl ester

There total 3 articles about Carbamic acid, [1-[2-[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3,3-trifluoro-1-(1-methyl ethyl)propyl]amino]-2-oxoethyl]-1,2-dihydro-2-oxo-6-phenyl-3-pyridinyl]-, (2,6-dimethyl-4-pyridinyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147269-02-1
2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

: 147283-55-4
(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid 2,6-dimethyl-pyridin-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 5 h / 760 Torr

2: Et₃N / CH₂Cl₂ / 0.75 h / 0 °C

3: CH₂Cl₂ / 0 - 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00046a016

Reference yield:

: 147283-34-9
2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

: 147283-55-4
(1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid 2,6-dimethyl-pyridin-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0.75 h / 0 °C

2: CH₂Cl₂ / 0 - 20 °C

With triethylamine; In dichloromethane;
DOI:10.1021/jm00046a016