18088-01-2

Usage

Uses

Used in Pharmaceutical Synthesis:
(2,6-DIMETHYLPYRIDIN-4-YL)METHANOL is used as a key intermediate for the development of pharmaceuticals due to its ability to be incorporated into the molecular structures of various drugs. Its presence can influence the pharmacological properties of these compounds, enhancing their efficacy and selectivity.
Used in Agrochemical Production:
In the agrochemical industry, (2,6-DIMETHYLPYRIDIN-4-YL)METHANOL serves as a crucial building block in the creation of pesticides and other agricultural chemicals. Its integration into these products can contribute to improved performance and targeted action against pests and diseases.
Used in Organic Chemistry Research:
(2,6-DIMETHYLPYRIDIN-4-YL)METHANOL is utilized as a research compound in organic chemistry, where its unique structure allows for exploration of new reactions and the synthesis of novel organic molecules. This contributes to the advancement of chemical knowledge and the discovery of new chemical entities.
Used in Biological Research and Development:
Possessing potential applications in biological research, (2,6-DIMETHYLPYRIDIN-4-YL)METHANOL may be employed in studies aimed at understanding biological processes or in the development of bioactive molecules. Its interaction with biological systems can provide insights into its therapeutic or diagnostic potential.

InChI:InChI=1/C8H11NO/c1-6-3-8(5-10)4-7(2)9-6/h3-4,10H,5H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 108-48-5 2,6-dimethylpyridine 
• 87117-15-5 1-methoxy-2,6-dimethylpyridinium methyl sulfate 
• 1073-23-0 2,6-lutidine N-oxide 

Downstream Products

• 147283-55-4 (1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-oxo-6-phenyl-1,2-dihydro-pyridin-3-yl)-carbamic acid 2,6-dimethyl-pyridin-4-ylmethyl ester 
• 79313-02-3 4-(bromomethyl)-2,6-dimethylpyridine 
• 120739-87-9 2,6-dimethyl-pyridin-4-ylmethyl chloride 
• 1198424-06-4 (2,6-dimethylpyridin-4-yl)methyl 4-nitrophenyl carbonate 
• 1352718-87-6 (2,6-dimethylpyridin-4-yl)methyl methanesulfonate 
• 18206-06-9 2,6-dimethyl-4-pyridine carboxaldehyde 
• 1246251-24-0 2-(2,6-dimethylpyridin-4-yl)-7-fluoro-5-(2-phenoxyethoxy)-3H-quinazolin-4-one 
• 1246251-23-9 2-(2,6-dimethylpyridin-4-yl)-7-methoxy-5-(2-phenoxyethoxy)quinazolin-4(3H)-one 
• 1246251-30-8 7-(2-(benzyloxy)ethoxy)-2-(2,6-dimethylpyridin-4-yl)-5-methoxyquinazolin-4(3H)-one 
• 1246251-22-8 2-(2,6-dimethylpyridin-4-yl)-5-methoxy-7-(2-phenoxyethoxy)quinazolin-4(3H)-one 
• 1198765-73-9 (2,6-dimethylpyridin-4-yl)methyl (1-methyl-1-phenylethyl)carbamate hydrochloride 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF OPTICALLY ENRICHED ISOXAZOLINES

The invention relates to a process for preparing optically enriched isoxazoline compounds of formula (I), formula (I), wherein the variables are as defined in the specification, and the shown enantiomer has at least 55% ee; by oxo-Michael addition of hydr

NEW COMPOUNDS AND USES THEREOF FOR DETECTION OF TARGET MOLECULES IN A SAMPLE

The present invention relates to new profluorophores and conjugates thereof and their use for the detection of target molecule in a sample, in particular nucleic acid target molecules. The invention relates to new profluorophores and new fluorophores and methods of use thereof particularly useful in the fields of diagnostics and quality control.

Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated "spin-center shift" (SCS) mechanism. Alcohols, however, remain underused as alkylating agents in synthetic chemistry due to their low reactivity in two-electron pathways. We report herein an enantioselective α-benzylation of aldehydes using alcohols as alkylating agents based on the mechanistic principle of spin-center shift. This strategy harnesses the dual activation modes of photoredox and organocatalysis, engaging the alcohol by SCS and capturing the resulting benzylic radical with a catalytically generated enamine. Mechanistic studies provide evidence for SCS as a key elementary step, identify the origins of competing reactions, and enable improvements in chemoselectivity by rational photocatalyst design.

Anti-inflammatory agents

Disclosed are novel compounds that are useful in regulating the expression of interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1), and their use in the treatment and/or prevention of cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s). Also, disclosed are compositions comprising the novel compounds, as well as methods for their preparation.

Selective photosensitization through an and logic response: Optimization of the pH and glutathione response of activatable photosensitizers

A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.

TREATMENT OF DISEASES BY EPIGENETIC REGULATION

The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.

Hydroxymethylation and carbamoylation of di- and tetramethylpyridines using radical substitution (minisci) reactions

Reaction of hydroxymethyl radicals with N-methoxy 2,4- and 2,6- dimethylpyridinium salts gave 2,4,6-substituted hydroxymethylpyridines. Similar reactions with 2,3,5,6-tetramethylpyridine and derivatives failed, however 4-substitution could be achieved using a carbamoyl radical.

AN IMPROVED METHOD FOR THE MONO-HYDROXYMETHYLATION OF PYRIDINES. A MODIFICATION OF THE MINISCI PROCEDURE

The reaction of N-methoxy-derivatives of pyridines in methanol with ammonium persulphate gives improved yields of mono-hydroxymethylated products.In contrast to the original Minisci procedure the reaction requires only catalytic amounts of ammonium persulphate.Evidence is presented which establishes that the reaction does not proceed via an intramolecular pathway.

Nucleophilic Substitution in Quaternary Salts of NN'-Linked Biazoles and Related Systems.

Some reactions of dicationic and monocationic N,N'-linked biazoles and of quaternized 1-(N-azolyl)pyridinium ions with nucleophiles have been studied.Although the pyrrolyl nucleus has been found to be a poor leaving group in these reactions, in other cases nucleophilic attack readily takes place at an azolyl carbon atom, with subsequent elimination of the N-substituent.The 1-methyl-3-(1-methyl-1,2,4-triazol-4-ylio)benzimidazolium dication (1) reacted at room temperature with ammonium, diethylamine, methoxyde, hydroxide, and cyanide ions, and with sodium borohydride, giving in all cases the corresponding 2-substituted benzimidazoles in good yield.In the case of the 2,4,6-trimethyl-1-(2-methylpyrazol-1-io)pyridinium dication (6), the reaction with cyanide ion afforded, regioselectively, 5-cyano-1-methylpyrazole, with no trace of the isomeric 3-cyano-1-methylpyrazole.The synthesis of the cations and dications from N-aminoazoles was easily performed.The reaction of 1-aminobenzimidazole with dehydroacetic acid in aqueous hydrochloric acid gave not only the expected 1-benzimidazol-1-yl-2,6-dimethylpyridin-4(1H)-one (9), but also 3-acetyl-1-benzimidazol-1-yl-4-hydroxy-6-methylpyridin-2(1H)-one (11).In pyridine, a pyran-2,4-dione intermediate (10), isomeric to (11), was also isolated.The quaternization reactions were easily performed, but high temperatures caused cleavage of the N-N bond.