4-[(2-Hydroxyethyl)amino]-4-oxobutanoic acid

Base Information

• Chemical Name: 4-[(2-Hydroxyethyl)amino]-4-oxobutanoic acid
• CAS No.: 147578-52-7
• Molecular Formula: C₆H₁₁NO₄
• Molecular Weight: 161.158
• DSSTox Substance ID: DTXSID20604084
• Nikkaji Number: J822.150B
• Wikidata: Q82501814
• Mol file: 147578-52-7.mol

Synonyms:147578-52-7;4-(2-Hydroxyethylamino)-4-oxobutanoic acid;4-[(2-Hydroxyethyl)amino]-4-oxobutanoic acid;Butanoic acid, 4-[(2-hydroxyethyl)amino]-4-oxo-;SCHEMBL2484600;DTXSID20604084;A1-05526

Chemical Property of 4-[(2-Hydroxyethyl)amino]-4-oxobutanoic acid

Chemical Property:

• Boiling Point: 483.3±30.0 °C(Predicted)
• PSA: 90.12000
• Density: 1.282±0.06 g/cm3(Predicted)
• LogP: -0.20000
• XLogP3: -1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 161.06880783
• Heavy Atom Count: 11
• Complexity: 146

Purity/Quality:

99% ^*data from raw suppliers

4-(2-Hydroxyethylamino)-4-oxobutanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)O)C(=O)NCCO

Technology Process of 4-[(2-Hydroxyethyl)amino]-4-oxobutanoic acid

There total 2 articles about 4-[(2-Hydroxyethyl)amino]-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinic acid anhydride (108-30-5) → 2-(succinyl)aminoethanol (147578-52-7)

Guidance literature:

succinic acid anhydride; NH₂(CH₂)2-O-2-chlorotrityl resin; With HATU;

With chlorotriisopropylsilane; trifluoroacetic acid; at 20 ℃; for 2h;

With piperidine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.12.052

Reference yield:

succinic acid anhydride (108-30-5) + ethanolamine (141-43-5) → 2-(succinyl)aminoethanol (147578-52-7)

Guidance literature:

With acetic acid; at 45 ℃;

DOI:10.1080/00304948.2013.798569

upstream raw materials:

succinic acid anhydride

ethanolamine