2-(Imidazo[1,2-a]pyridin-2-yl)ethanamine

Base Information

• Chemical Name: 2-(Imidazo[1,2-a]pyridin-2-yl)ethanamine
• CAS No.: 43170-96-3
• Molecular Formula: C₉H₁₁N₃
• Molecular Weight: 161.206
• Hs Code.: 2933990090
• European Community (EC) Number: 822-087-1
• DSSTox Substance ID: DTXSID60428706
• Nikkaji Number: J549.894E
• Wikidata: Q72482606
• Mol file: 43170-96-3.mol

Synonyms:43170-96-3;2-(imidazo[1,2-a]pyridin-2-yl)ethanamine;2-Imidazo[1,2-a]pyridin-2-yl-ethylamine;Imidazo[1,2-a]pyridine-2-ethanamine;2-imidazo[1,2-a]pyridin-2-ylethanamine;2-(IMIDAZO[1,2-A]PYRIDIN-2-YL)ETHAN-1-AMINE;2-{imidazo[1,2-a]pyridin-2-yl}ethan-1-amine;(2-imidazo[1,2-a]pyridin-2-ylethyl)amine;SCHEMBL2732396;DTXSID60428706;BBL030636;MFCD06738922;STL249301;AKOS000272748;AB28183;2-imidazo[1,2-a]pyridin-2-ylethylamine;2-(Imidazo[1,2-a]pyridin-2-yl)ethylamine;2-(2-aminoethyl)imidazo [1,2-a] pyridine;2-(imidazo[1,2-a]pyridine-2-yl)ethanamine;BB 0216590;CS-0452475;FT-0695045;EN300-26646;F2184-0030;N,N,N,N-BIS(TETRAMETHYLENE)-O-(1,2-DIHYDRO-2-OXO-1-PYRIDYL)URONIUMHEXAFLUOROPHOSPHATE

Chemical Property of 2-(Imidazo[1,2-a]pyridin-2-yl)ethanamine

Chemical Property:

• Refractive Index: 1.641
• PSA: 43.32000
• Density: 1.21 g/cm³
• LogP: 1.53580
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 161.095297364
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

2-Imidazo[1,2-a]pyridin-2-yl-ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC(=CN2C=C1)CCN

Technology Process of 2-(Imidazo[1,2-a]pyridin-2-yl)ethanamine

There total 7 articles about 2-(Imidazo[1,2-a]pyridin-2-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile (57892-77-0) → 2-(2-aminoethyl)imidazo<1,2-a>pyridine (43170-96-3)

Guidance literature:

2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile; With dimethylsulfide borane complex; In tetrahydrofuran; at 80 ℃; for 2h;

With methanol; In tetrahydrofuran; at 10 - 80 ℃; for 1h;

Reference yield:

boronic acid R1-B(OH)2 + 7-Iodo-2-(2-(quinolin-2-yl)ethyl)isoindolin-1-one (1417190-43-2) → 2-(2-aminoethyl)imidazo<1,2-a>pyridine (43170-96-3)

Guidance literature:

Pd(dppf)Cl₂; In 1,4-dioxane; water;

Reference yield:

3-Oxo-2-(2-(quinolin-2-yl)ethyl)isoindolin-4-ylboronic acid (1417190-44-3) → 2-(2-aminoethyl)imidazo<1,2-a>pyridine (43170-96-3)

Guidance literature:

Pd(dppf)Cl₂; In 1,4-dioxane; water;

upstream raw materials:

2-chloromethylimidazo[1,2-a]pyridine

2-aminopyridine

2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile

7-Iodo-2-(2-(quinolin-2-yl)ethyl)isoindolin-1-one

Downstream raw materials:

C₂₀H₁₉N₃O₃

Refernces

• 1、 -. "NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A". . . Retrieved 2013/02/28.