57892-77-0

Usage

Uses

Used in Pharmaceutical Industry:
IMIDAZO[1,2-A]PYRIDIN-2-YLACETONITRILE is used as a key building block for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into a wide range of drug candidates, potentially leading to the discovery of novel treatments for numerous diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical field, IMIDAZO[1,2-A]PYRIDIN-2-YLACETONITRILE is utilized as a component in the development of new agrochemicals. Its incorporation into these products can contribute to the creation of innovative solutions for pest control and crop protection, enhancing agricultural productivity and sustainability.
Used in Cancer Research:
IMIDAZO[1,2-A]PYRIDIN-2-YLACETONITRILE is used as a research reagent in cancer research. Its potential anti-cancer properties make it a promising candidate for further investigation into its ability to inhibit the growth of cancer cells, which could lead to the development of new cancer therapies.
Used in Chemical Research and Development:
As a research reagent, IMIDAZO[1,2-A]PYRIDIN-2-YLACETONITRILE is employed in the development of new chemical compounds for various applications. Its unique structure and properties make it a valuable tool for researchers working in both the pharmaceutical and agricultural industries, facilitating the creation of innovative products and solutions.

InChI:InChI=1/C9H7N3/c10-5-4-8-7-12-6-2-1-3-9(12)11-8/h1-3,6-7H,4H2

Upstream product

• 151-50-8 potassium cyanide 
• 57892-76-9 2-chloromethylimidazo[1,2-a]pyridine 
• 274-76-0 imidazo[1,2-a]pyridine 
• 504-29-0 2-aminopyridine 

Downstream Products

• 1062183-94-1 2-{3-[(E)-2-(4-methoxyphenyl)diazenyl]-imidazo[1,2-a]pyridin-2-yl}-2-[(Z)-2-(4-methoxyphenyl)hydrazono]acetonitrile 
• 1062183-93-0 (2Z)-{3-[(E)-phenyldiazenyl]imidazo[1,2-a]-pyridin-2-yl}(phenylhydrazono)acetonitrile 
• 43170-96-3 2-(2-aminoethyl)imidazo<1,2-a>pyridine 

Relevant academic research and scientific papers

INDOLE AHR INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

New fluorescent heterocyclic systems from imidazo[1,2-a]pyridine: Design, synthesis, spectral studies and quantum-chemical investigations

Two new fluorescent heterocyclic systems dipyrido[1′,2′:1,2]imidazo[4,5-b:4,5-e]pyridine-13-carbonitrile and pyrido[1′,2′:1,2]imidazo[4,5-b]pyrido[2′,1′:2,3]imidazo[4,5-e]pyridine-13-carbonitrile were synthesized by one-pot reaction of imidazo[1,2-a]pyridine with 2-(imidazo[1,2-a]pyridin-3-yl)acetonitrile and 2-(imidazo[1,2-a]pyridin-2-yl)acetonitrile, respectively, in MeOH/KOH solution via the nucleophilic substitution of hydrogen in high yields. Spectral and analytical data have confirmed the structures of the synthesized dyes. The optical and solvatochromic properties of the compounds were investigated and the results showed that they exhibited interesting photophysical properties. Density functional theory (DFT) calculations of fluorescent dyes were performed to provide the optimized geometries and relevant frontier orbitals by using the B3LYP hybrid functional and the 6–311?++ G(d,p) basis set. Calculated electronic absorption spectra were also obtained by time-dependent density functional theory (TD-DFT) method. In addition, electron density iso-surface map, intra- and intermolecular interactions of these fluorescent heterocyclic systems were evaluated by AIM (Atoms in Molecules) analysis.

NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A

The present invention relates to novel carboxamide compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating or controlling medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders

Synthesis and properties of cyanomethyl derivatives of imidazo[1,2-a] pyridine, imidazo[1,2-a]pyrimidine, and imidazo[2,1-b]thiazole

2-Cyanomethyl derivatives were obtained of imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine, and imidazo[2,1-b]thiazole, and their reactivity was investigated by an example of imidazo[1,2-a]pyridine: It was subjected to nitration, bromination, azo coupling and nitrosation. Acylation of the methylene group effected by amino acids esters with a subsequent addition of the amino group to the cyano group resulted in the formation of 5-amino-4-imidazo[1,2-a]- pyridin-2-yl-1-phenyl-1,2-dihydro-3H-pyrrol-3-one and 2-amino-1-ethyl-3- imidazol[1,2-a]pyridin-2-yl-4(1H)-quinolinone.