2,7-Dimethyl-1,8-naphthyridine

Base Information

• Chemical Name: 2,7-Dimethyl-1,8-naphthyridine
• CAS No.: 14903-78-7
• Molecular Formula: C10H10N2
• Molecular Weight: 158.20000
• Hs Code.: 2933990090
• Mol file: 14903-78-7.mol

Synonyms:1,8-Naphthyridine,2,7-dimethyl;

Chemical Property of 2,7-Dimethyl-1,8-naphthyridine

Chemical Property:

• Melting Point: 194-195 °C
• Boiling Point: 259.7±35.0 °C(Predicted)
• PKA: 4.81±0.30(Predicted)
• PSA: 25.78000
• Density: 1.109±0.06 g/cm3(Predicted)
• LogP: 2.24660

Purity/Quality:

99% ^*data from raw suppliers

2,7-DIMETHYL-1,8-NAPHTHYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,7-Dimethyl-1,8-naphthyridine

There total 23 articles about 2,7-Dimethyl-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,7-dimethyl-4-chloro-1,8-naphthyridine (84670-41-7) → 2,7-dimethyl-[1,8]naphthyridine (14903-78-7)

Guidance literature:

With potassium hydroxide; hydrogen; Lindlar's catalyst; In methanol; for 5h; under 3040 Torr;

DOI:10.1016/S0040-4020(00)00748-1

Reference yield: 92.0%

2,7-dimethyl-1,8-naphthyridine-4(1H)-one (53051-92-6) → 2,7-dimethyl-[1,8]naphthyridine (14903-78-7)

Guidance literature:

With potassium hydroxide; hydrogen; Lindlar's catalyst; In methanol;

Reference yield: 90.0%

methyllithium (917-54-4) + 2-methyl-[1,8]naphthyridine (1569-16-0) → 2,7-dimethyl-[1,8]naphthyridine (14903-78-7)

Guidance literature:

With potassium permanganate; In diethyl ether; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.201903724

upstream raw materials:

2,7-Dimethyl-1,2-dihydro-1,8-naphthyridine

1,2,7-trimethyl-1,8-napthyridinium iodide

2,7-dimethyl-1,8-naphthyridine-4(1H)-one

methanol

Downstream raw materials:

1,8-naphthyridine-2,7-dicarboxaldehyde

2,7-bis(N,N-dibenzyl-aminomethyl)-1,8-naphthyridine

2,7-bis{2-[2-(1-methyl)benzimidazolylethyl]-N-benzyl-aminomethyl}-1,8-naphthyridine

(2,7-dimethyl-1,8-naphthyridine)bis(2,6-di(p-tolyl)benzoato)iron(II)