1569-16-0

Basic information

• Product Name: 2-METHYL-[1,8]NAPHTHYRIDINE
• Synonyms: AKOS BBS-00006025;2-METHYL-[1,8]NAPHTHYRIDINE
• CAS NO: 1569-16-0
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• Product Categories: Heterocycle-Pyridine series
• Mol File: 1569-16-0.mol
• Article Data: 40

Chemical Properties

• Melting Point: 96-97°C
• Boiling Point: 252.835 °C at 760 mmHg
• Flash Point: 106.326 °C
• Appearance: /
• Density: 1.142 g/cm³
• Vapor Pressure: 0.0301mmHg at 25°C
• Refractive Index: 1.633
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.02±0.30(Predicted)
• CAS DataBase Reference: 2-METHYL-[1,8]NAPHTHYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-[1,8]NAPHTHYRIDINE(1569-16-0)
• EPA Substance Registry System: 2-METHYL-[1,8]NAPHTHYRIDINE(1569-16-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1569-16-0(Hazardous Substances Data)

Usage

General Description

2-Methyl-[1,8]naphthyridine is a chemical compound with a naphthyridine ring system. It is a heterocyclic compound with a molecular formula C13H11N. 2-METHYL-[1,8]NAPHTHYRIDINE is important in the field of organic chemistry and pharmaceuticals, as it serves as a building block for the synthesis of various biologically active molecules and pharmaceutical drugs. 2-Methyl-[1,8]naphthyridine may also have potential applications in materials science and environmental chemistry. Its unique structure and properties make it a valuable tool for researchers and chemists working in a variety of disciplines.

InChI:InChI=1/C9H8N2/c1-7-4-5-8-3-2-6-10-9(8)11-7/h2-6H,1H3

Upstream product

• 2802-08-6 (E)-4-(dimethylamino)but-3-en-2-one 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 7521-41-7 2-Aminonicotinaldehyde 
• 815-68-9 3-acetylpentane-2,4-dione 
• 110-89-4 piperidine 
• 1824-81-3 2-Amino-6-methylpyridine 
• 107-18-6 allyl alcohol 
• 147-85-3 L-proline 
• 86847-64-5 N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide 
• 504-29-0 2-aminopyridine 
• 107-02-8 acrolein 
• 56-81-5 glycerol 
• 15121-66-1 4-Hydroxy-4-phenyl-2-pentanone 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 

Downstream Products

• 85191-50-0 (E)-2-styryl-1,8-naphthyridine 
• 123302-67-0 2-Methoxy-6-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-phenol 
• 721920-80-5 ethyl (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)acetate 
• 724771-26-0 3-[2-(4-chloro-phenyl)-thiazol-5-yl]-4-{3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-ethoxy]-isoxazol-5-yl}-butyric acid ethyl ester 
• 243641-39-6 2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethanol 
• 243641-37-4 tert-butyl 7-methyl-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate 
• 64379-45-9 1,8-naphthyridine-2-carboxaldehyde 
• 925889-81-2 tert-butyl 7-(2-methoxy-2-oxoethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate 
• 204452-91-5 3(S)-(6-methoxypyridin-3-yl)-3-alanine tert-butyl ester p-toluenesulfonic acid 
• 204452-90-4 2-(dimethoxymethyl)-1,8-naphthyridine 
• 65896-28-8 1,8-naphthyridine-2,7-dicarboxaldehyde 
• 125158-69-2 Dimethyl-[4-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-phenyl]-amine 

Relevant articles and documents

A mild synthesis of substituted 1,8-naphthyridines

A greener method for the synthesis of substituted 1,8-naphthyridines has been developed, which is supported by reaction metric analysis. Using 2-aminonicotinaldehyde as a starting material with a variety of carbonyl reaction partners, the Friedl?nder reac

Synthesis of 1,8-naphthyridine and BF2-based isomers and their application in fluorogenic sensing Cd2+

A series of isomers were synthesized and identified, two isomers of which were developed as the dual-channel fluorescent probe toward Cd2+. BF2 dissociates from the probe upon reaction with CdCl2, demonstrating a new approach for sensing Cd2+.

High-selectivity fibroblast growth factor receptor inhibitor and application

The invention discloses a high-selectivity fibroblast growth factor receptor inhibitor and application, and particularly relates to a compound shown in a formula (I) or a pharmaceutically acceptable salt, a solvate, a geometric isomer, a stereoisomer, a tautomer and any mixture thereof. The compound shown in the formula (I) or the pharmaceutically acceptable salt, the solvate and the pharmaceutical composition thereof can be applied to prevention or treatment of diseases related to FGFR4 activity or overexpression, and can also be combined with other medicines to be used for treating various related diseases, especially for treating various cancers, wherein the cancers may be liver cancer, lung cancer, gastric cancer, breast cancer, ovarian cancer, prostate cancer, renal cell carcinoma, skin cancer, colon cancer, bile duct cancer, glioma or sarcoma.

Cooperative H2 Activation on Dicopper(I) Facilitated by Reversible Dearomatization of an “Expanded PNNP Pincer” Ligand

A naphthyridine-derived expanded pincer ligand is described that can host two copper(I) centers. The proton-responsive ligand can undergo reversible partial and full dearomatization of the naphthyridine core, which enables cooperative activation of H2 giving an unusual butterfly-shaped Cu4H2 complex.