1569-16-0

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-[1,8]NAPHTHYRIDINE is utilized as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique structure allows for the development of new medications with potential applications in treating a wide range of diseases and conditions.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2-METHYL-[1,8]NAPHTHYRIDINE serves as a valuable compound for studying the properties and reactions of heterocyclic systems. It aids chemists in understanding the reactivity and selectivity of naphthyridine-based compounds, which can lead to the discovery of novel chemical reactions and synthetic pathways.
Used in Materials Science:
2-METHYL-[1,8]NAPHTHYRIDINE may have potential applications in materials science, where its unique structural features could be employed to design and develop new materials with specific properties. These materials could find use in various industries, such as electronics, coatings, or advanced materials for specific applications.
Used in Environmental Chemistry:
In environmental chemistry, 2-METHYL-[1,8]NAPHTHYRIDINE could be explored for its potential use in the development of new environmental technologies. Its unique chemical properties might contribute to the creation of innovative solutions for pollution control, environmental monitoring, or the remediation of contaminated sites.

InChI:InChI=1/C9H8N2/c1-7-4-5-8-3-2-6-10-9(8)11-7/h2-6H,1H3

Upstream product

• 77972-44-2 1,7-dimethyl-1,8-naphthyridinium iodide 
• 7521-41-7 2-Aminonicotinaldehyde 
• 147-85-3 L-proline 
• 254-60-4 1,8-naphthyridine 
• 67-68-5 dimethyl sulfoxide 
• 86847-64-5 N-(3-formyl-2-pyridinyl)-2,2-dimethylpropanamide 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 504-29-0 2-aminopyridine 
• 1824-81-3 2-Amino-6-methylpyridine 
• 107-02-8 acrolein 
• 107-18-6 allyl alcohol 
• 56-81-5 glycerol 
• 15121-66-1 4-Hydroxy-4-phenyl-2-pentanone 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 

Downstream Products

• 85191-50-0 (E)-2-styryl-1,8-naphthyridine 
• 123302-67-0 2-Methoxy-6-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-phenol 
• 123302-66-9 2-((E)-2-[1,8]Naphthyridin-2-yl-vinyl)-4-nitro-phenol 
• 125094-48-6 2-(4-Phenyl-1,3-butadienyl)-1,8-naphthyridine 
• 123302-64-7 2,4-Dibromo-6-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-phenol 
• 123302-68-1 4-Bromo-2-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-6-nitro-phenol 
• 129919-41-1 1a,1b,2,7b-tetrahydro-1b-methyl-1,2-bis(phenylsulfonyl)-1H-azirino<1.2-a>cyclopropa<1.8>naphthyridine 
• 129919-40-0 1a,1b,2,7b-tetrahydro-5-methyl-1,2-bis(phenylsulfonyl)-1H-azirino<1.2-a>cyclopropa<1.8>naphthyridine 
• 123302-65-8 2-((E)-2-[1,8]Naphthyridin-2-yl-vinyl)-6-nitro-phenol 
• 123302-69-2 4-Bromo-2-methoxy-6-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-phenol 
• 125094-45-3 2-Methoxy-6-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-4-nitro-phenol 
• 123302-61-4 4-Chloro-2-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-phenol 
• 123302-63-6 4-Bromo-2-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-phenol 
• 123302-62-5 2,4-Dichloro-6-((E)-2-[1,8]naphthyridin-2-yl-vinyl)-phenol 

Relevant academic research and scientific papers

A mild synthesis of substituted 1,8-naphthyridines

A greener method for the synthesis of substituted 1,8-naphthyridines has been developed, which is supported by reaction metric analysis. Using 2-aminonicotinaldehyde as a starting material with a variety of carbonyl reaction partners, the Friedl?nder reac

Synthesis of 1,8-naphthyridine and BF2-based isomers and their application in fluorogenic sensing Cd2+

A series of isomers were synthesized and identified, two isomers of which were developed as the dual-channel fluorescent probe toward Cd2+. BF2 dissociates from the probe upon reaction with CdCl2, demonstrating a new approach for sensing Cd2+.

Olefin oxygenation by water on an iridium center

Oxygenation of 1,5-cyclooctadiene (COD) is achieved on an iridium center using water as a reagent. A hydrogen-bonding interaction with an unbound nitrogen atom of the naphthyridine-based ligand architecture promotes nucleophilic attack of water to the met

High-selectivity fibroblast growth factor receptor inhibitor and application

The invention discloses a high-selectivity fibroblast growth factor receptor inhibitor and application, and particularly relates to a compound shown in a formula (I) or a pharmaceutically acceptable salt, a solvate, a geometric isomer, a stereoisomer, a tautomer and any mixture thereof. The compound shown in the formula (I) or the pharmaceutically acceptable salt, the solvate and the pharmaceutical composition thereof can be applied to prevention or treatment of diseases related to FGFR4 activity or overexpression, and can also be combined with other medicines to be used for treating various related diseases, especially for treating various cancers, wherein the cancers may be liver cancer, lung cancer, gastric cancer, breast cancer, ovarian cancer, prostate cancer, renal cell carcinoma, skin cancer, colon cancer, bile duct cancer, glioma or sarcoma.

ALPHAvBETA1 INTEGRIN ANTAGONISTS

The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ανβ1 and/or α5β1. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ανβ3, ανβ5, ανβ6, ανβ8, and/or αIIbβ3.

PYRROLOPYRAZINE DERIVATIVES AS ALPHA V INTEGRIN INHIBITORS

The disclosure relates to compounds of formula I: Formula I which inhibit αv-containing integrins, and includes pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αV-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders.

Cooperative H2 Activation on Dicopper(I) Facilitated by Reversible Dearomatization of an “Expanded PNNP Pincer” Ligand

A naphthyridine-derived expanded pincer ligand is described that can host two copper(I) centers. The proton-responsive ligand can undergo reversible partial and full dearomatization of the naphthyridine core, which enables cooperative activation of H2 giving an unusual butterfly-shaped Cu4H2 complex.

Transition metal-free α-methylation of 1,8-naphthyridine derivatives using DMSO as methylation reagent

A practical approach to the direct α-methylation of 1,8-naphthyridines under mild reaction conditions has been developed using simple and readily available DMSO as a convenient and environmentally friendly carbon source. This method is transition metal-free and highly chemoselective, shows good functional group tolerance, and uses DMSO as a methyl source, providing efficient and rapid access to an important compound class, 2-methyl-1,8-naphthyridines.

INTEGRIN ANTAGONISTS

The present disclosure provides pharmaceutical agents, including those of the formula:(I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Meth

A four-hydrogenated 1, 8 - naphthyridine apperception composition preparation method and its prepared chiral products

The invention discloses a preparation method of a tetrahydro 1, 8-naphthyridine compound. The preparation method comprises the following steps: under the existence of a chiral catalyst, enabling a compound with the structure shown in the formula (1) (in the description) and hydrogen to be subjected to addition reaction, wherein the chiral catalyst is a coordination compound with the structure shown in the formula (2) (in the description). The invention further provides a chiral product of the tetrahydro 1, 8-naphthyridine compound, prepared through the preparation method. According to the invention, the proper compound with the structure shown in the formula (1) (in the description) is used as a substrate, and the proper coordination compound with the structure shown in the formula (2) (in the description) is used as the chiral catalyst to perform selective hydrogenation reduction on 1, 8-naphthyridine compound with the structure shown in the formula (1) by adopting hydrogen, so that the chiral product of the tetrahydro 1, 8-naphthyridine compound is prepared with low cost. The chiral product of the tetrahydro 1, 8-naphthyridine compound can be used as a biologically active compound and a structural building block of a chiral drug.