N-CYCLOHEXYL-GUANIDINE

Base Information

• Chemical Name: N-CYCLOHEXYL-GUANIDINE
• CAS No.: 14948-83-5
• Molecular Formula: C7H15N3
• Molecular Weight: 141.216
• Hs Code.: 2925290090
• Mol file: 14948-83-5.mol

Synonyms:Cyclohexylguanidin;Cyclohexylguanidine;1-cyclohexyl-guanidine;N-cyclohexylquanidine;N-Cyclohexylguanidine;cyclohexylamine-N-carboxamidine;Guanidine,cyclohexyl;

Chemical Property of N-CYCLOHEXYL-GUANIDINE

Chemical Property:

• Vapor Pressure: 0.075mmHg at 25°C
• Boiling Point: 228.12oC at 760 mmHg
• PKA: 13.81±0.70(Predicted)
• Flash Point: 91.764oC
• PSA: 61.90000
• Density: 1.23g/cm3
• LogP: 1.99310
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

cyclohexylguanidine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-CYCLOHEXYL-GUANIDINE

There total 11 articles about N-CYCLOHEXYL-GUANIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

cyclohexylamine (108-91-8,157973-60-9) + 4-benzyl-3,5-dimethyl-1H-pyrazole-1-carboximidamide hydrochloride → N-cyclohexylquanidine (14948-83-5)

Guidance literature:

With triethylamine; In acetonitrile; at 60 ℃; for 24h;

DOI:10.1016/S0040-4039(01)02403-0 DOI:10.1055/s-2006-926284

Reference yield: 72.0%

cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexylquanidine (14948-83-5)

Guidance literature:

In methanol; for 4h; Ambient temperature;

DOI:10.1016/0040-4039(88)85116-5

Reference yield: 69.0%

polystyrene-bound 3,5-dimethyl-1H-pyrazole-1-carboxamidine hydrochloride, <= 1.8 mmol active pyrazole-1-carboxamidine groups per gram resin + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexylquanidine (14948-83-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 60 ℃; for 24h;

DOI:10.1055/s-2006-926284

upstream raw materials:

CYANAMID

cyclohexylamine hydrochloride

3,5-dimethyl-1-pyrazolylformaminidium nitrate

cyclohexylamine

Downstream raw materials:

cyclohexylcarbamimidoyl-amidophosphoric acid dibenzyl ester

Monoacetyl-cyclohexylguanidin

Refernces

• 1、 Dr?ger, Gerald,Solodenko, Wladimir,Messinger, Josef,Sch?n, Uwe,Kirschning, Andreas. "A new reagent and its polymer-supported variant for the amidination of amines". . p. 1401 - 1403. Retrieved 2007/10/03.
• 2、 Kim, Keekyung,Lin, Yi-Tsong,Mosher, Harry S.. "MONOSUBSTITUTED GUANIDINES FROM PRIMARY AMINES AND AMINOIMINOMETHANESULFONIC ACID". . p. 3183 - 3186. Retrieved 2007/10/02.