Dimethyl (4-methoxybenzoyl)propanedioate

Base Information

Chemical Name:Dimethyl (4-methoxybenzoyl)propanedioate
CAS No.:149652-25-5
Molecular Formula:C13H14O6
Molecular Weight:266.251
Hs Code.:
DSSTox Substance ID:DTXSID80572053
Nikkaji Number:J1.438.976H
Wikidata:Q82460295
Mol file:149652-25-5.mol

Synonyms:149652-25-5;dimethyl 4-methoxybenzoylmalonate;Dimethyl (4-methoxybenzoyl)propanedioate;DTXSID80572053

Suppliers and Price of Dimethyl (4-methoxybenzoyl)propanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Dimethyl (4-methoxybenzoyl)propanedioate

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:266.07903816
Heavy Atom Count:19
Complexity:327

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=O)C(C(=O)OC)C(=O)OC

Technology Process of Dimethyl (4-methoxybenzoyl)propanedioate

There total 3 articles about Dimethyl (4-methoxybenzoyl)propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 100-07-2
4-methoxy-benzoyl chloride

: 108-59-8
malonic acid dimethyl ester

: 149652-25-5
dimethyl 2-(4-methoxybenzoyl)malonate

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 3h;
DOI:10.1080/00397910008086983

Reference yield: 54.0%

: 2-chloro-2-(dimethylamino-phenyl-methyl)-malonic acid dimethyl ester

: 149652-25-5
dimethyl 2-(4-methoxybenzoyl)malonate

Guidance literature:: With sodium methylate; In methanol;
DOI:10.1023/A:1015090426917

Reference yield:

: 28868-76-0
2-chlorodimethylmalonate

: 149652-25-5
dimethyl 2-(4-methoxybenzoyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: t-BuOK / tetrahydrofuran; dimethylformamide / 1 h / -70 - -20 °C

2: 54 percent / NaOMe / methanol

With potassium tert-butylate; sodium methylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Knoevenagel reaction / 2: Knoevenagel reaction;
DOI:10.1023/A:1015090426917