Ethanone, 1-[4-(2-naphthalenyl)phenyl]-

Base Information

• Chemical Name: Ethanone, 1-[4-(2-naphthalenyl)phenyl]-
• CAS No.: 150988-77-5
• Molecular Formula: C18H14O
• Molecular Weight: 246.309
• DSSTox Substance ID: DTXSID00431971
• Nikkaji Number: J2.566.392F
• Wikidata: Q82246020
• Mol file: 150988-77-5.mol

Synonyms:150988-77-5;Ethanone, 1-[4-(2-naphthalenyl)phenyl]-;1-(4-(Naphthalen-2-yl)phenyl)ethanone;1-(4-naphthalen-2-ylphenyl)ethanone;4'-(2-Naphthyl)acetophenone;SCHEMBL18260221;DTXSID00431971;AKOS005820974;1-[4-(naphthalen-2-yl)phenyl]ethan-1-one

Chemical Property of Ethanone, 1-[4-(2-naphthalenyl)phenyl]-

Chemical Property:

• Melting Point: 129-130 °C
• Boiling Point: 407.9±14.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.117±0.06 g/cm3(Predicted)
• LogP: 4.70940
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 246.104465066
• Heavy Atom Count: 19
• Complexity: 314

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)C2=CC3=CC=CC=C3C=C2

Technology Process of Ethanone, 1-[4-(2-naphthalenyl)phenyl]-

There total 19 articles about Ethanone, 1-[4-(2-naphthalenyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

naphthalene-2-boronic acid (32316-92-0) + para-bromoacetophenone (99-90-1) → 1-(4-(naphthalen-2-yl)phenyl)ethan-1-one (150988-77-5)

Guidance literature:

With Br^(1-)*C₂₈H₂₉BrN₅O₂Pd⁽¹⁺⁾; potassium carbonate; In water; at 100 ℃; for 3h;

DOI:10.1039/c0dt01083a

Reference yield: 95.0%

2-bromonaphthalene (580-13-2) + 4-acetylphenylboronic acid (149104-90-5) → 1-(4-(naphthalen-2-yl)phenyl)ethan-1-one (150988-77-5)

Guidance literature:

With caesium carbonate; In water; N,N-dimethyl-formamide; at 40 ℃; for 21h; Inert atmosphere;

DOI:10.1016/j.tet.2017.12.056

Reference yield: 95.0%

4-Iodoacetophenone (13329-40-3) + naphthalene-2-boronic acid (32316-92-0) → 1-(4-(naphthalen-2-yl)phenyl)ethan-1-one (150988-77-5)

Guidance literature:

With 1,2,3-Benzotriazole; palladium diacetate; potassium carbonate; In water; N,N-dimethyl-formamide; at 60 ℃;

upstream raw materials:

1,4-dihydronaphthalene-1,4-epoxide

4-Iodoacetophenone

2-Methoxynaphthalene

1-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)ethan-1-one

Downstream raw materials:

2-bromo-1-[4-(naphthalen-2-yl)phenyl]ethanone