1-(MethoxyMethyl)-3-nitrobenzene

Base Information

• Chemical Name: 1-(MethoxyMethyl)-3-nitrobenzene
• CAS No.: 1515-84-0
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Hs Code.: 2909309090
• Mol file: 1515-84-0.mol

Synonyms:m-nitrobenzyl methyl ether;1-methoxymethyl-3-nitrobenzene;3-nitrobenzyl methyl ether;

Chemical Property of 1-(MethoxyMethyl)-3-nitrobenzene

Chemical Property:

• PSA: 17.07000
• LogP: 3.39980

Purity/Quality:

97% ^*data from raw suppliers

1-(Methoxymethyl)-3-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(MethoxyMethyl)-3-nitrobenzene

There total 10 articles about 1-(MethoxyMethyl)-3-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

sodium methylate (124-41-4) + 3-Nitrobenzyl chloride (619-23-8) → 1-(methoxymethyl)-3-nitrobenzene (1515-84-0)

Guidance literature:

With methanol; for 2h; Reflux;

DOI:10.1021/ja106076h

Reference yield: 82.0%

sodium methylate (124-41-4) + 1-bromomethyl-3-nitrobenzene (3958-57-4) → 1-(methoxymethyl)-3-nitrobenzene (1515-84-0)

Guidance literature:

In methanol; N,N-dimethyl-formamide; for 5h; Reflux; Inert atmosphere; Cooling with ice;

Reference yield: 75.0%

3-Nitrobenzyl alcohol (619-25-0) + methyl iodide (74-88-4) → 1-(methoxymethyl)-3-nitrobenzene (1515-84-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2006.11.005

upstream raw materials:

3-Nitrobenzyl alcohol

dimethyl sulfate

sodium methylate

3-Nitrobenzyl chloride

Downstream raw materials:

3-(1-methoxymethyl)phenylamine

3-nitro-benzaldehyde

methyl 3-nitrobenzoate

α-hydroperoxy-m-nitrobenzyl methyl ether