3-Phenyl-1-pyrrolidin-1-ylpropan-1-one

Base Information

• Chemical Name: 3-Phenyl-1-pyrrolidin-1-ylpropan-1-one
• CAS No.: 151647-54-0
• Molecular Formula: C13H17NO
• Molecular Weight: 203.284
• DSSTox Substance ID: DTXSID901328664
• Nikkaji Number: J978.349K
• ChEMBL ID: CHEMBL1334206
• Mol file: 151647-54-0.mol

Synonyms:3-phenyl-1-(pyrrolidin-1-yl)propan-1-one;151647-54-0;3-phenyl-1-pyrrolidin-1-ylpropan-1-one;MLS001195188;1-Pyrrolizino-3-phenylpropanal;SCHEMBL3700679;CHEMBL1334206;DTXSID901328664;HMS2825L08;MFCD01175587;STK014859;AKOS003236898;SMR000503098;3-Phenyl-1-(pyrrolidin-1-yl)-propan-1-one;Z31480282

Chemical Property of 3-Phenyl-1-pyrrolidin-1-ylpropan-1-one

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 203.131014166
• Heavy Atom Count: 15
• Complexity: 203

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCN(C1)C(=O)CCC2=CC=CC=C2

Technology Process of 3-Phenyl-1-pyrrolidin-1-ylpropan-1-one

There total 64 articles about 3-Phenyl-1-pyrrolidin-1-ylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + hydrocinnamic acid chloride (645-45-4) → 3-phenyl-1-pyrrolidin-1-yl-propane-1-one (151647-54-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jacs.6b04061

Reference yield: 96.0%

pyrrolidine (123-75-1) + (E)-2-hydroxy-2-methyl-5-phenylpent-4-en-3-one (63677-96-3) → 3-phenyl-1-pyrrolidin-1-yl-propane-1-one (151647-54-0)

Guidance literature:

With 1,2,4-Triazole; C₆H₁₀N₃O₂S⁽¹⁺⁾*Cl^(1-); N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 3h;

DOI:10.1039/b909360e

Reference yield: 95.0%

pyrrolidine (123-75-1) + 3-phenylpropanoic acid fluoride (458-69-5) → 3-phenyl-1-pyrrolidin-1-yl-propane-1-one (151647-54-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1039/d0gc03912h

upstream raw materials:

pyrrolidine

3-Phenylpropionic acid

4-phenyl-2-(pyrrolidin-1-yl)butanenitrile

3-phenyl-propionaldehyde

Downstream raw materials:

2-benzyl-1-hydroxy-1-phenylhex-5-en-3-one

2-benzyl-3-[(trimethylsilyl)methyl]cyclobutanone

C₁₃H₁₆FNO

1-(5-bromo-1H-indol-3-yl)-3-phenylpropan-1-one