N,N-tetramethylene 2-benzyl-3-oxopropanoamide

Base Information

• Chemical Name: N,N-tetramethylene 2-benzyl-3-oxopropanoamide
• CAS No.: 86576-77-4
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 86576-77-4.mol

Synonyms:N,N-tetramethylene 2-benzyl-3-oxopropanoamide

Chemical Property of N,N-tetramethylene 2-benzyl-3-oxopropanoamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-tetramethylene 2-benzyl-3-oxopropanoamide

There total 2 articles about N,N-tetramethylene 2-benzyl-3-oxopropanoamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

benzyl bromide (100-39-0) + N,N-tetramethylene 3-morpholinylpropenoamide (81238-98-4) → N,N-tetramethylene 2-benzyl-3-oxopropanoamide (86576-77-4)

Guidance literature:

In acetonitrile; at 60 ℃; for 16h; Mechanism;

DOI:10.1016/0040-4020(82)80066-5

Reference yield:

Methyl formate (107-31-3) + 3-phenyl-1-pyrrolidin-1-yl-propane-1-one (151647-54-0) → N,N-tetramethylene 2-benzyl-3-oxopropanoamide (86576-77-4)

Guidance literature:

3-phenyl-1-pyrrolidin-1-yl-propane-1-one; With lithium diisopropyl amide; In diethyl ether; at -78 - 0 ℃; for 1.16667h; Inert atmosphere;

Methyl formate; In diethyl ether; at -78 - 20 ℃; for 12h;

DOI:10.1021/jacs.5b09593

Reference yield: 97.0%

n-octyne (629-05-0) + N,N-tetramethylene 2-benzyl-3-oxopropanoamide (86576-77-4) → C22H31NO2 + 2-benzyl-4-methylene-1-(pyrrolidin-1-yl)decane-1,3-dione

Guidance literature:

With [Rh(tBu₂PCH₂P(o-C₆H₄OMe)₂)(C₆H₅F)][3,5-(CF₃)₂C₆H₃]; In acetone; at -20 ℃; for 18h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.7b05713

upstream raw materials:

benzyl bromide

N,N-tetramethylene 3-morpholinylpropenoamide

Methyl formate

3-phenyl-1-pyrrolidin-1-yl-propane-1-one