4-(DIPHENYLHYDROXYMETHYL)BENZOIC ACID

Base Information

• Chemical Name: 4-(DIPHENYLHYDROXYMETHYL)BENZOIC ACID
• CAS No.: 19672-49-2
• Molecular Formula: C20H16 O3
• Molecular Weight: 304.345
• Hs Code.: 2918199090
• Mol file: 19672-49-2.mol

Synonyms:p-Toluicacid, a-hydroxy-a,a-diphenyl- (8CI); NSC 408493; a-Hydroxy-a,a-diphenyl-p-toluic acid

Chemical Property of 4-(DIPHENYLHYDROXYMETHYL)BENZOIC ACID

Chemical Property:

• Vapor Pressure: 2.83E-11mmHg at 25°C
• Melting Point: 210-215 °C
• Boiling Point: 511.2°Cat760mmHg
• PKA: 4.24±0.10(Predicted)
• Flash Point: 277.1°C
• PSA: 57.53000
• Density: 1.253g/cm³
• LogP: 3.66900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Diphenylhydroxymethyl)benzoic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Precursor of a new trityl linker. It is ideally suited for coupling with TentaGel: 4-(Diphenylhydroxymethyl)benzoic Acid reactant for antitumor kinesin spindle protein inhibitors.

Technology Process of 4-(DIPHENYLHYDROXYMETHYL)BENZOIC ACID

There total 28 articles about 4-(DIPHENYLHYDROXYMETHYL)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(4-methylphenyl)diphenylmethanol (5440-76-6) → 4-(diphenylhydroxymethyl)benzoic acid (19672-49-2)

Guidance literature:

With nitric acid;

Reference yield: 67.0%

benzophenone (119-61-9) + 4-Bromobenzoic acid (586-76-5) → 4-(diphenylhydroxymethyl)benzoic acid (19672-49-2)

Guidance literature:

4-Bromobenzoic acid; With n-butyllithium; In tetrahydrofuran; hexane; at -65 ℃; for 0.0833333h;

benzophenone; In tetrahydrofuran; hexane; at -65 - 20 ℃;

With hydrogenchloride; In water; pH=4;

Reference yield:

2-(4-benzhydryl-phenyl)-1,3-diphenyl-indene (859932-38-0) + acetic acid (64-19-7,77671-22-8) → 4-(diphenylhydroxymethyl)benzoic acid (19672-49-2) + o-dibenzoylbenzene (1159-86-0)

Guidance literature:

DOI:10.1021/ja01299a005

upstream raw materials:

p-(diphenylmethyl)toluene

(4-methylphenyl)diphenylmethanol

4-(diphenylmethyl)benzaldehyde

4-benzhydrylbenzoic acid

Downstream raw materials:

(4-(hydroxymethyl)phenyl)(diphenyl)methanol

4-(α-hydroxy-benzhydryl)-benzoic acid methyl ester

C₂₈H₃₁NO₄

N-(7-(hydroxyamino)-7-oxoheptyl)-4-(hydroxydiphenylmethyl)benzamide

Refernces

• 1、 -. "REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF". Page/Page column 83. . Retrieved 2011/08/08.
• 2、 -. "PROCESS FOR PEPTIDE SYNTHESIS OF PEPTIDES CONTAINING A 4-HYDROXY-PROLINE SUBSTRUCTURE". Page 16-17. . Retrieved 2008/06/13.