(E)-1-Nitro-2-phenylpropene

Base Information

• Chemical Name: (E)-1-Nitro-2-phenylpropene
• CAS No.: 15241-24-4
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.176
• Mol file: 15241-24-4.mol

Synonyms:α-methyl-β-nitrostyrene;(E)-2-phenyl-1-nitroprop-1-ene;(E)-1-nitro-2-phenyl-1-propene;trans-Alpha-methyl-Beta-nitrostyrene;(E)-(1-nitroprop-1-en-2-yl)benzene;(E)-2-phenyl-1-nitro-1-propene;(E)-1-nitro-2-phenylprop-1-ene;

Chemical Property of (E)-1-Nitro-2-phenylpropene

Chemical Property:

• PSA: 45.82000
• LogP: 2.84730

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-1-Nitro-2-phenylpropene

There total 21 articles about (E)-1-Nitro-2-phenylpropene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → (E)-1-nitro-2-phenyl-1-propene (5670-65-5,15795-70-7,15241-24-4)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; silver nitrate; In 1,2-dichloro-ethane; at 70 ℃; for 12h; Molecular sieve;

DOI:10.1002/chem.202100889

Reference yield: 93.0%

1-benzylthio-1-nitromethyl-1-phenylethane → 1-nitro-2-phenylpropene (5670-65-5,15241-24-4,15795-70-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In 1,2-dichloro-ethane; for 4h; Heating;

DOI:10.1016/S0040-4020(03)00754-3

Reference yield: 88.0%

nitromethane (75-52-5) + acetophenone (98-86-2) → (E)-1-nitro-2-phenyl-1-propene (5670-65-5,15795-70-7,15241-24-4)

Guidance literature:

With ammonium acetate; In acetic acid; at 90 ℃; for 5h; Reflux;

DOI:10.1016/j.tet.2013.02.084

upstream raw materials:

2-acetoxy-1-nitro-2-phenylpropane

isopropenylbenzene

nitromethane

acetophenone

Downstream raw materials:

4-Nitro-3-phenyl-2-triphenylphosphoranylidenvaleriansaeuremethylester

2-phenylpropanal oxime

(+)-(R)-1-nitro-2-phenylpropane

(S)-1-nitro-2-phenylpropane

Refernces

• 1、 Pirola, Margherita,Faverio, Chiara,Orlandi, Manuel,Benaglia, Maurizio. "Metal-Free Deoxygenation of Chiral Nitroalkanes: An Easy Entry to α-Substituted Enantiomerically Enriched Nitriles". supporting information. p. 10247 - 10250. Retrieved 2021/06/18.
• 2、 Wang, Ye,Zheng, Lei,Shi, Xiaodong,Chen, Yunfeng. "1,3-Difunctionalization of β-alkyl nitroalkenes via combination of Lewis base catalysis and radical oxidation". supporting information. p. 886 - 889. Retrieved 2021/02/01.