1-benzothioylpyrrolidine

Base Information

• Chemical Name: 1-benzothioylpyrrolidine
• CAS No.: 15563-45-8
• Molecular Formula: C11H13NS
• Molecular Weight: 191.297
• Mol file: 15563-45-8.mol

Synonyms:1-thiobenzoylpyrrolidine;1-(Phenylthioxomethyl)pyrrolidine;1-Benzothioylpyrrolidine;thiobenzopyrrolidide;HMS2842F03;

Chemical Property of 1-benzothioylpyrrolidine

Chemical Property:

• PSA: 35.33000
• LogP: 2.39580

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzothioylpyrrolidine

There total 23 articles about 1-benzothioylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + Benzoylformic acid (611-73-4) → 1-thiobenzoylpyrrolidine (15563-45-8)

Guidance literature:

With sulfur; In benzene; at 80 ℃; for 0.166667h;

DOI:10.1016/S0040-4020(01)86099-3

Reference yield: 99.0%

n-benzoylpyrrolidine (3389-54-6) → 1-thiobenzoylpyrrolidine (15563-45-8)

Guidance literature:

With Lawessons reagent; In benzene; for 12h; Ambient temperature;

DOI:10.1021/jo00081a011

Reference yield: 95.0%

pyrrolidine (123-75-1) + benzaldehyde (100-52-7) → 1-thiobenzoylpyrrolidine (15563-45-8)

Guidance literature:

With sulfur; In neat (no solvent); at 100 ℃; for 0.5h; Green chemistry;

DOI:10.1007/s00706-017-1944-6

upstream raw materials:

pyrrolidine

O,O-diethyl benzylphosphonate

benzoyl chloride

Benzoylformic acid

Downstream raw materials:

(2-Oxo-2-phenyl-ethyl)-[1-phenyl-1-pyrrolidin-1-yl-meth-(E)-ylidene]-sulfonium; bromide

Refernces

• 1、 Zhang, Jin,Liu, Ying,Jia, Qiangqiang,Wang, Yue,Ma, Yangmin,Szostak, Michal. "Ruthenium(II)-catalyzed C-H arylation of N,N-dialkyl thiobenzamides with boronic acids by sulfur coordination in 2-MeTHF". supporting information. p. 6884 - 6890. Retrieved 2020/09/15.
• 2、 Nguyen, Thanh Binh,Nguyen, Le Phuong Anh,Nguyen, Thi Thu Tram. "Sulfur-Catalyzed Oxidative Coupling of Dibenzyl Disulfides with Amines: Access to Thioamides and Aza Heterocycles". supporting information. p. 1787 - 1791. Retrieved 2019/02/26.