2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(trifluoromethyl)-

Base Information

• Chemical Name: 2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(trifluoromethyl)-
• CAS No.: 156136-54-8
• Molecular Formula: C10H8F3NO
• Molecular Weight: 215.17200
• Mol file: 156136-54-8.mol

Synonyms:1-Methyl-5-trifluoromethyl-1,3-dihydro-indol-2-one;1-methyl-5-(trifluoromethyl)oxindole;5-trifluoromethyl-1-methyloxindole;

Chemical Property of 2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(trifluoromethyl)-

Chemical Property:

• Melting Point: 127.5 - 129 °C (hexane)
• Boiling Point: 339.6±42.0 °C(Predicted)
• PSA: 20.31000
• Density: 1.348±0.06 g/cm3(Predicted)
• LogP: 2.28930

Purity/Quality:

1-Methyl-5-(trifluoromethyl)indolin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(trifluoromethyl)-

There total 7 articles about 2H-Indol-2-one, 1,3-dihydro-1-methyl-5-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C10H9BrF3NO → 1-methyl-5-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one (156136-54-8)

Guidance literature:

With 5% Pd/C; Cs₂CO₃; tricyclohexylphosphine; Trimethylacetic acid; at 140 ℃; for 2h; Green chemistry;

DOI:10.1016/j.mcat.2022.112211

Reference yield: 65.0%

5-trifluoromethyl-2-indolinone (71293-62-4) + dimethyl sulfate (77-78-1) → 1-methyl-5-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one (156136-54-8)

Guidance literature:

With sodium hydroxide; In water; Heating;

DOI:10.1021/jm00039a016

Reference yield: 50.0%

tetrachloromethane (56-23-5) + N-methyl-2-indolinone (61-70-1) → 1-methyl-5-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one (156136-54-8)

Guidance literature:

With hydrogen fluoride; antimony pentafluoride; at 0 ℃; for 2h;

DOI:10.1016/j.tetlet.2003.10.192

upstream raw materials:

5-trifluoromethyl-2-indolinone

dimethyl sulfate

tetrachloromethane

N-methyl-2-indolinone

Downstream raw materials:

1-Methyl-2-thioxo-5-trifluoromethyl-2,3-dihydro-1H-indole-3-carboxylic acid phenylamide

1-methyl-5-(trifluoromethyl)-2-indolinethione