Diethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:Diethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:34148-67-9
Molecular Formula:C19H22 Cl N O4
Molecular Weight:363.841
Hs Code.:
NSC Number:143354
DSSTox Substance ID:DTXSID30301431
Nikkaji Number:J626.660F
ChEMBL ID:CHEMBL2063821

Synonyms:34148-67-9;diethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylicacid, 4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester;NSC143354;Oprea1_099928;Oprea1_352640;SCHEMBL3017208;CHEMBL2063821;DTXSID30301431;HQAADEKEJNBOLM-UHFFFAOYSA-N;STK371012;AKOS000653046;NSC-143354;3,5-diethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;EU-0001906;EN300-18296203;Z57568087;3,5-dicarboethoxy-2,6-dimethyl-4-(2-chlorophenyl)-1,4-dihydropyridine;4-(2-CHLORO-PH)-2,6-DIMETHYL-1,4-2H-PYRIDINE-3,5-DICARBOXYLIC ACID DIETHYL ESTER;diethyl 4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate

Suppliers and Price of Diethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of Diethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Vapor Pressure:1.08E-08mmHg at 25°C
Boiling Point:461.3°Cat760mmHg
Flash Point:232.8°C
Density:1.191g/cm³
XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:363.1237359
Heavy Atom Count:25
Complexity:556

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OCC)C)C

Technology Process of Diethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 8 articles about Diethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 141-97-9
ethyl acetoacetate

: 89-98-5
2-chloro-benzaldehyde

: 34148-67-9
diethyl 2,6-dimethyl-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With 1%Cu/ZnO; ammonium acetate; In water; for 0.7h; Reflux; Green chemistry;
DOI:10.1007/s11164-014-1712-8

Reference yield: 90.0%

: 104-88-1
4-chlorobenzaldehyde

: 539-88-8
4-oxopentanoic acid ethyl ester

: 34148-67-9
diethyl 2,6-dimethyl-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With ammonium acetate; In neat (no solvent); at 55 ℃; for 5h; Green chemistry;
DOI:10.1055/s-0034-1379477

Reference yield: 87.0%

: 631-61-8,92206-38-7
ammonium acetate

: 141-97-9
ethyl acetoacetate

: 89-98-5
2-chloro-benzaldehyde

: 34148-67-9
diethyl 2,6-dimethyl-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: ammonium acetate; ethyl acetoacetate; 2-chloro-benzaldehyde; With cellulose sulfuric acid; In neat (no solvent); at 80 - 100 ℃;

With cellulose sulfuric acid; In neat (no solvent);
DOI:10.1016/j.bmcl.2012.05.003