[(R)-1-(Ethoxycarbonyl)ethyl]carbamic acid benzyl ester

Base Information

Chemical Name:[(R)-1-(Ethoxycarbonyl)ethyl]carbamic acid benzyl ester
CAS No.:157774-53-3
Molecular Formula:C13H17NO4
Molecular Weight:251.282
Hs Code.:
DSSTox Substance ID:DTXSID101235263
Nikkaji Number:J1.184.710B
Mol file:157774-53-3.mol

Synonyms:DTXSID101235263;N-[(Phenylmethoxy)carbonyl]-D-alanine ethyl ester;[(R)-1-(Ethoxycarbonyl)ethyl]carbamic acid benzyl ester;157774-53-3

Suppliers and Price of [(R)-1-(Ethoxycarbonyl)ethyl]carbamic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(R)-1-(Ethoxycarbonyl)ethyl]carbamic acid benzyl ester

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:251.11575802
Heavy Atom Count:18
Complexity:274

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(C)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES:CCOC(=O)[C@@H](C)NC(=O)OCC1=CC=CC=C1

Technology Process of [(R)-1-(Ethoxycarbonyl)ethyl]carbamic acid benzyl ester

There total 12 articles about [(R)-1-(Ethoxycarbonyl)ethyl]carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 245364-56-1
C₁₉H₂₀N₂O₈S

: 157774-53-3
N-<(phenylmethoxy)carbonyl>-D-alanine ethyl ester

Guidance literature:: With potassium carbonate; thiophenol; In N,N-dimethyl-formamide; at 23 ℃; for 1h;
DOI:10.1055/s-1999-2827

Reference yield: 80.0%

: 64-17-5
ethanol

: 26607-51-2
N-benzyloxycarbonyl-D-alanine

: 157774-53-3
N-<(phenylmethoxy)carbonyl>-D-alanine ethyl ester

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; for 12h; Ambient temperature;
DOI:10.1021/jo00126a080

Reference yield:

: 18815-73-1
methylzinc iodide

: 134746-23-9
ethyl 2-(((benzyloxy)carbonyl)amino)-2-chloroacetate

: 60625-90-3,72604-33-2
Cbz-alanine ethyl ester

: 157774-53-3
N-<(phenylmethoxy)carbonyl>-D-alanine ethyl ester

Guidance literature:: With nickel(II) bromide dimethoxyethane; 2,6-bis((4S,5R)-4-isopropyl-5-phenyl-4,5-dihydrooxazol-2-yl)pyridine; In tetrahydrofuran; at 0 ℃; for 4h; Overall yield = 75 percent; Overall yield = 113 mg; enantioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1021/jacs.1c03903