2-(2-Chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone

Base Information

Chemical Name:2-(2-Chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone
CAS No.:158876-69-8
Molecular Formula:C13H9ClFNO
Molecular Weight:249.672
Hs Code.:
DSSTox Substance ID:DTXSID50446151
Wikidata:Q82264738
Mol file:158876-69-8.mol

Synonyms:2-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone;158876-69-8;SCHEMBL2980415;DTXSID50446151;YELDSRZWSMAJAM-UHFFFAOYSA-N

Suppliers and Price of 2-(2-Chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-(2-Chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone

Chemical Property:

PSA：29.96000
LogP:3.29950
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:249.0356698
Heavy Atom Count:17
Complexity:266

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)CC2=CC(=NC=C2)Cl)F

Technology Process of 2-(2-Chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone

There total 3 articles about 2-(2-Chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 3678-62-4
2-chloro-4-picoline

: 116332-54-8
4-fluoro-N-methoxy-N-methylbenzamide

: 158876-69-8
2-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone

Guidance literature:: 2-chloro-4-picoline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -85 ℃; for 1h;

4-fluoro-N-methoxy-N-methylbenzamide; In tetrahydrofuran; hexane; at -85 - 0 ℃; for 2h;
DOI:10.1021/jm030766k

Reference yield:

: 3678-62-4
2-chloro-4-picoline

: 116332-54-8
4-fluoro-N-methoxy-N-methylbenzamide

: 1,3-bis-(2-chloropyridin-4-yl)-2-(4-fluorophenyl)-propan-2-ol

: 158876-69-8
2-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone

Guidance literature:: 2-chloro-4-picoline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -85 - -50 ℃; for 1h;

4-fluoro-N-methoxy-N-methylbenzamide; In tetrahydrofuran; hexane; at -85 - 0 ℃; for 2.05h;