[1,1'-Biphenyl]-2-carboxamide

Base Information

• Chemical Name: [1,1'-Biphenyl]-2-carboxamide
• CAS No.: 13234-79-2
• Molecular Formula: C13H11 N O
• Molecular Weight: 197.236
• Hs Code.: 2924299090
• European Community (EC) Number: 236-206-4
• UNII: Y5NK5ET4ND
• DSSTox Substance ID: DTXSID80157501
• Nikkaji Number: J102.244J
• Wikidata: Q72443645
• ChEMBL ID: CHEMBL3794311
• Mol file: 13234-79-2.mol

Synonyms:2-Phenylbenzamide;[1,1'-Biphenyl]-2-carboxamide;13234-79-2;biphenyl-2-carboxamide;2-Biphenylcarboxamide;(1,1'-Biphenyl)-2-carboxamide;Y5NK5ET4ND;1,1'-biphenyl-2-carboxamide;CHEMBL3794311;EINECS 236-206-4;phenylbenzamide;biphenyl amide;UNII-Y5NK5ET4ND;SCHEMBL132986;DTXSID80157501;BDBM50162486;MFCD00075754;AKOS006242753;FT-0696665;Z57336477

Chemical Property of [1,1'-Biphenyl]-2-carboxamide

Chemical Property:

• Melting Point: 179-180℃
• Boiling Point: 378.5oC at 760 mmHg
• Flash Point: 182.7oC
• PSA: 43.09000
• Density: 1.137g/cm3
• LogP: 3.15280
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 197.084063974
• Heavy Atom Count: 15
• Complexity: 221

Purity/Quality:

99% ^*data from raw suppliers

2-Phenylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=CC=C2C(=O)N
• Uses: 2-Phenylbenzamide is a derivative of benzamide, a building block compound of various pharmaceutical goods ranging from analgesics to antipsychotics.

Technology Process of [1,1'-Biphenyl]-2-carboxamide

There total 27 articles about [1,1'-Biphenyl]-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

o-phenylbenzoyl chloride (14002-52-9) → 2-phenylbenzamide (13234-79-2)

Guidance literature:

With ammonium hydroxide; benzylamine; In dichloromethane; toluene; at 0 ℃; for 2.0002h; Solvent;

Reference yield: 96.0%

2-Bromobenzamide (4001-73-4) + phenylboronic acid (98-80-6) → 2-phenylbenzamide (13234-79-2)

Guidance literature:

With palladium diacetate; diisopropylamine; In water; at 100 ℃; for 1h; Sealed tube; Green chemistry;

DOI:10.1039/c2gc36098e

Reference yield: 93.0%

N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide (1088187-91-0) → 2-phenylbenzamide (13234-79-2)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In water; at 60 ℃; for 3h; Reagent/catalyst; Temperature; chemoselective reaction;

DOI:10.1021/acs.joc.9b01362

upstream raw materials:

9-fluorenone

2-chloro-7-phenyltropone

2-chloro-3-phenyltropolone

2-Biphenylcarboxylic acid

Downstream raw materials:

N,N'-bis(o-phenylphenyl)formamidine

2-phenylaniline

2-Biphenylcarboxylic acid

6(5H)-phenanthridinone